Reservoirs with subretinal cannula for subretinal drug delivery
First Claim
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1. A subretinal delivery device comprising:
- a reservoir;
a cannula extending from the reservoir, the cannula having a length and being configured such that it extends from the reservoir through the vitreous and through the retina with a distal end terminating in a subretinal space when the reservoir is disposed exterior the eye on the sclera or when the reservoir is disposed within the eye;
a securing mechanism near the distal end of the cannula configured to secure a distal portion of the cannula to the retina; and
wherein the cannula is configured so that an agent in the reservoir is released from the reservoir through the cannula to the eye subretinally.
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Accused Products
Abstract
Featured are devices and methods for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. Such instillation is accomplished by providing a reservoir containing a therapeutic medium to which is fluidly coupled a cannula and inserting a portion of the cannula sub-retinally, whereby the therapeutic medium within the reservoir is coupled to and dispersed subretinally via the cannula.
37 Citations
27 Claims
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1. A subretinal delivery device comprising:
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a reservoir; a cannula extending from the reservoir, the cannula having a length and being configured such that it extends from the reservoir through the vitreous and through the retina with a distal end terminating in a subretinal space when the reservoir is disposed exterior the eye on the sclera or when the reservoir is disposed within the eye; a securing mechanism near the distal end of the cannula configured to secure a distal portion of the cannula to the retina; and wherein the cannula is configured so that an agent in the reservoir is released from the reservoir through the cannula to the eye subretinally. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for the treatment of ocular conditions comprising the steps of:
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implanting an agent delivery device comprising a reservoir and a cannula extending from the reservoir into the eye such that the reservoir is disposed exterior the eye on the sclera or within the eye, with the cannula extending from the reservoir through the retina into a subretinal space; and allowing the agent in the reservoir to be delivered to the eye via the cannula subretinally. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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27. A subretinal delivery device comprising:
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a reservoir; a cannula extending from the reservoir; the cannula having a length and being configured to extend from the reservoir through the vitreous and through the retina into a subretinal space when the reservoir is disposed exterior the eye on the sclera or when the reservoir is disposed within the eye; the cannula having a pointed distal end for insertion through the retina, the distal end and at least a distal portion of the cannula having a cross-sectional size that allows for disposal and retainment within the subretinal space between the retina and choroid of the eye; and wherein an agent in the reservoir is released through the cannula to the eye subretinally.
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Specification