Phase change sensor

• US 7,794,657 B2
• Filed: 05/28/2004
• Issued: 09/14/2010
• Est. Priority Date: 06/03/2003
• Status: Expired due to Fees

• Current Assignee: Cantimer, Inc.
• Original Assignee: Cantimer, Inc.
• Inventors: Stewart, Ray F.
• Primary Examiner(s): Jung; Unsu
• Application Number:
  US10/857,634
• Publication Number:
  US 20050164299A1
• Time in Patent Office: 2,300 Days
• Field of Search: 422/68.1, 436/148
• US Class Current: 422/82.01
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

A device is disclosed which is a highly sensitive and selective sensor. The device is comprised of a sensor material secured into a fixed position on substrate, a deformable arm and a signaling component which creates a detectable signal in response to movement of the arm. The sensitivity of the device is enhanced by using a sensor material which undergoes a dramatic change in volume which may be accompanied by a phase change in response contact with a target such a molecule of interest. The selectivity of the device is enhanced by incorporating highly specific binding receptors (e.g. antibodies) into the sensor material which receptors bind to specific targets (e.g. peptide epitopes). The binding of the target molecule to the receptor causes the sensor material to change dramatically in volume thereby moving the arm causing the signaling component (e.g. a piezoresistor) to create a detectable signal (e.g. change in resistance) thereby indicating the present of the target.

Claims

1. A sensor device, comprising:

a sensing material which responds to a change in osmolality of a solution by a change in volume, said sensing material comprising more than about 50% by weight of a polymerized hydroxypropyl acrylate monomer;

a deformable arm comprising a first end connected to a substrate and a second end positioned such that it is moved in response to the volumetric change of the sensing material; and

a signaling component which creates a detectable signal in response to deformation of the arm caused by movement of the second end of the arm.

2. The sensor device of claim 1, wherein the volumetric change is an increase in volume.

3. The sensor device of claim 1, wherein the sensing material undergoes a volumetric change of 50% or more in response to a change in osmolality.

4. The sensor of claim 1, wherein the sensing material is a hydrogel.

5. The sensor of claim 1, wherein the sensing material undergoes a phase transition in response to a change in osmolality.

6. The sensor device of claim 1, wherein the volumetric change is a decrease in volume.

7. The sensor device of claim 1, wherein the signaling component is chosen from a piezoresistor, a piezoelectric component, and a capacitor.

8. The sensor device of claim 7, further comprising:

a source of voltage connected to the arm and applying an electrical potential difference between two points on the arm.

9. The sensor device of claim 8, further comprising:

a meter connected to the arm capable of measuring a change in resistance of the piezoresistor.

10. The sensor device of claim 1, wherein the second end of the arm is positioned with a space between the second end and a surface of the sensing material.

11. The sensor device of claim 10, wherein the space is 1 millimeter or less.

12. The sensor device of claim 1, wherein the second end of the arm is connected to the sensing material.

13. The sensor device of claim 1, wherein the second end of the arm is positioned inside the sensing material.

14. The device of claim 1, wherein the sensing material comprises a receptor that selectively binds a target molecule, the receptor comprising a chemical moiety bound to the polymer sensing material.

15. The device of claim 14, wherein the chemical moiety is a hydroxyl chemical moiety on the polymer sensing material.

16. The device of claim 15, wherein the chemical moiety is a hydroxyl chemical moiety on a hydroxypropyl acrylate unit of the polymer sensing material.