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Vascularization enhanced graft constructs

  • US 7,795,022 B2
  • Filed: 05/02/2003
  • Issued: 09/14/2010
  • Est. Priority Date: 05/02/2002
  • Status: Active Grant
First Claim
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1. A remodelable tissue graft construct having vessel-like structures for implantation into a host for use in repairing diseased or damaged tissues, said tissue graft construct comprising(i) a matrix composition selected from the group consisting of liver basement membrane, extracts of liver basement membrane, and hydrolysates of liver basement membrane,(ii) added endothelial cells,(iii) at least one additional preselected, exogenous population of cells, and(iv) vessel-like structures, wherein said additional population of cells enhances the initiation of formation of said vessel-like structures in said graft construct.

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