Anti-angiogenic methods and compositions
First Claim
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1. A method for modulating angiogenesis in a human or a mouse animal, the method comprising introducing a zinc finger protein into a human or mouse animal having a genome, the genome comprising a target site within a pigment epithelium derived factor (PEDF) gene, whereby the zinc finger protein binds to the target site and thereby modulates angiogenesis in the animal, wherein the zinc finger protein binds to a target site specified in Table 1 (SEQ ID NOs:
- 8-13) and further wherein the zinc finger protein further comprises a functional domain.
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Abstract
Disclosed herein are methods and compositions for treatment of conditions requiring inhibition of angiogenesis. Such conditions include those characterized by neovascularization, such as retinopathies, macular degeneration and various malignancies.
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6 Claims
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1. A method for modulating angiogenesis in a human or a mouse animal, the method comprising introducing a zinc finger protein into a human or mouse animal having a genome, the genome comprising a target site within a pigment epithelium derived factor (PEDF) gene, whereby the zinc finger protein binds to the target site and thereby modulates angiogenesis in the animal, wherein the zinc finger protein binds to a target site specified in Table 1 (SEQ ID NOs:
- 8-13) and further wherein the zinc finger protein further comprises a functional domain.
- View Dependent Claims (2, 3, 4, 5, 6)
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