Protective role of semapimod in necrotizing enterocolitis

• US 7,795,314 B2
• Filed: 06/01/2006
• Issued: 09/14/2010
• Est. Priority Date: 06/01/2005
• Status: Active Grant

• Current Assignee: Ferring BV (Ferring Holding SA), University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: Cytokine PharmaSciences Inc. (Ferring Holding SA)
• Inventors: Zamora, Ruben, Ford, Henri R., Sielecki-Dzurdz, Thais, De La Cruz, Vidal F.
• Primary Examiner(s): Spivack; Phyllis G.
• Application Number:
  US11/421,666
• Publication Number:
  US 20070282005A1
• Time in Patent Office: 1,566 Days
• Field of Search: None
• US Class Current: 514/615
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 33/06 Antimalarials

Abstract

A method is described wherein semapimod is administered, or a salt thereof, or a combination of semapimod and a salt thereof, for the treatment of necrotizing enterocolitis.

Claims

1. A method, comprising administering to a subject in need thereof, a compound having the following formula:

2. The method of claim 1, wherein the subject is a human subject.

3. The method of claim 1, wherein the subject is a human infant.

4. The method of claim 1, wherein the compound is in the salt form.

5. The method of claim 1, wherein the compound, salt thereof, or a combination of the compound and a salt thereof, is administered in the form of a composition further comprising at least one carrier.

6. The method of claim 1, wherein the salt is a salt of L-lactic acid.

7. The method of claim 1, wherein the salt is a bromide, iodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, citrate, acid citrate, tartrate, bitartrate, succinate, fumarate, tosylate, mesylate, gluconate, saccharate, benzoate, methanesulfonate, ethanesulfonate, benzenesulfonate, or pamoate salt of said compound.

8. The method of claim 1, wherein the salt is a bicarbonate, edetate, camsylate, carbonate, dihydrochloride, edisylate, estolate, gluceptate, glucoheptonate, glutamate, hydrobromide, hydrochloride, hydroxynaphthoate, chloride, isethionate, lactate, malate, mandelate, methyibromide, methylnitrate, methylsulfate, mucate, napsylate, pantothenate, diphosphate, salicylate, stearate, subacetate, tannate, teoclate, or triethiodide salt of said compound.

9. The method of claim 1, wherein the salt is an acid addition salt of hydrochloric, phosphoric, acetic, oxalic, tartaric, or mandelic acid.