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Porcine animals lacking any expression of functional alpha 1, 3 galactosyltransferase

  • US 7,795,493 B2
  • Filed: 08/21/2003
  • Issued: 09/14/2010
  • Est. Priority Date: 08/21/2002
  • Status: Active Grant
First Claim
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1. A method for the production of a pig that lacks any expression of functional alpha-1,3 galactosyltransferase (α

  • -1,3 GT) comprising;

    breeding a male pig heterozygous for an inactivation of the alpha-1,3 GT gene with a female pig heterozygous for an inactivation of the α

    -1,3 GT gene, wherein one or both pigs are heterozygous due to the presence of a point mutation in an allele of the α

    -1,3 GT gene, wherein the point mutation is a T-to-G point mutation at the second base of exon 9 of the α

    -1,3 GT gene or a point mutation induced or produced by a genetic modification in the α

    -1,3 GT gene.

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