Transcutaneous neurostimulator for modulating cardiovascular function

• US 7,797,041 B2
• Filed: 10/11/2006
• Issued: 09/14/2010
• Est. Priority Date: 10/11/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kramer, Andrew P., Libbus, Imad, Caparso, Anthony V.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Porter, Jr.; Gary A
• Application Number:
  US11/548,359
• Publication Number:
  US 20080091256A1
• Time in Patent Office: 1,434 Days
• Field of Search: 607/59, 607/60, 607/149, 607 30- 33, 607/36, 607/37, 607/142, 607/145, 607/2, 128/903, 128/907, 600/523
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: Y10S 128/907 Acupuncture

Abstract

A neurostimulation device includes an external neurostimulator worn by a patient using a bracing element that braces a portion of the patient'"'"'s body. The external neurostimulator delivers neurostimulation to modulate a cardiovascular function of the patient. In one embodiment, the external stimulator delivers the neurostimulation transcutaneously to a stimulation target in the patient'"'"'s body using surface stimulation electrodes placed on the body approximately over the stimulation target.

Claims

1. A method for modulating a cardiovascular function in a body by transcutaneous neurostimulation, the method comprising:

holding an external neurostimulator on surface of the body using a bracing element configured to brace a portion of the body;

placing surface stimulation electrodes on the body, including placing at least one of the surface stimulation electrodes on acupuncture point GB-34 on the Gall Bladder Meridian;

delivering neurostimulation transcutaneously to the acupuncture point from the external neurostimulator through the surface stimulation electrodes in response to an acute myocardial infarction (MI);

controlling the delivery of the neurostimulation by executing a stimulation algorithm stored in a memory circuit of the external neurostimulator, the stimulation algorithm including parameters selected to modulate the cardiovascular function; and

timing the delivery of the neurostimulation according to a programmed schedule using a clock of the external neurostimulator.

2. The method of claim 1, wherein delivering the neurostimulation comprises delivering electrical neurostimulation pulses at a stimulation frequency between approximately 1 to 5 Hz.

3. The method of claim 2, wherein delivering the neurostimulation comprises delivering the electrical neurostimulation pulses for approximately 0.5 to 24 hours each day.

4. The method of claim 1, further comprising sensing a feedback control signal, and wherein controlling the delivery of the neurostimulation comprises controlling the delivery of the neurostimulation using the feedback control signal.

5. The method of claim 4, wherein sensing the feedback control signal comprising sensing the feedback control signal using an implantable medical device.

6. The method of claim 1, wherein placing the at least one of the surface stimulation electrodes on the acupuncture point comprises placing one or more of the surface stimulation electrodes on one or more of acupuncture points including:

PC-2 through PC-9 on the Pericardium Meridian;

HT-7 on the Heart Meridian;

BL-14 and BL-16 on the Bladder Meridian; and

GV-11 on the Governing Vessel Meridian.

7. The method of claim 1, wherein placing the surface stimulation electrodes comprises placing at least one of the surface stimulation electrodes on the body over a nerve of the autonomic nervous system that modulates the cardiovascular function.

8. The method of claim 1, wherein placing the surface stimulation electrodes on the body comprises placing at least one of the surface stimulation electrodes approximately over an acupuncture point of the body at which electrical stimulation is known to have anti-remodeling and anti-arrhythmia effects.

9. The method of claim 1, comprising generating an alarm signal as a reminder of the timed delivery of the neurostimulation.