Apparatus and method for rangings and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands

• US 7,797,119 B2
• Filed: 12/13/2007
• Issued: 09/14/2010
• Est. Priority Date: 01/24/2002
• Status: Expired due to Term

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Bouma, Brett Eugene, Tearney, Guillermo J., de Boer, Johannes F.
• Primary Examiner(s): Barbee; Manuel L
• Application Number:
  US11/956,129
• Publication Number:
  US 20080097709A1
• Time in Patent Office: 1,006 Days
• Field of Search: 702/66, 702/69, 702/72, 702/79, 702/89, 702/189, 356/73.1, 356/477, 356/479, 356/480, 356/5.1, 356/5.12, 385/3
• US Class Current: 702/89
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01B 2290/45 Multiple detectors for detecting interferometer signals
• CPC Class Codes: G01B 9/02007 Two or more frequencies or sources used for interferometric measurement using only beat G01B9/02003
• CPC Class Codes: G01B 9/02008 by using a frequency comb
• CPC Class Codes: G01B 9/0201 using temporal phase variation
• CPC Class Codes: G01B 9/02032 generating a spatial carrier frequency, e.g. by creating lateral or angular offset between reference and object beam shearing interferometers G01B9/02098
• CPC Class Codes: G01B 9/02044 Imaging in the frequency domain, e.g. by using a spectrometer
• CPC Class Codes: G01B 9/02045 using the Doppler effect
• CPC Class Codes: G01B 9/02079 Quadrature detection, i.e. detecting relatively phase-shifted signals
• CPC Class Codes: G01B 9/0209 Low-coherence interferometers
• CPC Class Codes: G01B 9/02091 Tomographic interferometers, e.g. based on optical coherence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

Claims

1. An apparatus for controlling a phase of a signal, comprising:

a system which is configured to;

(a) obtain at least one interference signal which is based on a first signal from a sample and a second signal from a reference;

(b) during (a), modulate the phase of the at least one interference signal to produce first information;

(c) determine offset information between the first signal and the second signal based on the first information;

(d) control the phase of the at least one interference signal using the offset information to generate second information; and

(e) generate an image which includes a plurality of depth profiles of at least a portion of the sample using the second information.

2. The apparatus according to claim 1, wherein the first information includes a modulated interference signal.

3. The apparatus according to claim 1, wherein the system is further configured to demodulate the first information using at least one periodic signal, and wherein the offset information is determined based on the demodulated first information.

4. The apparatus according to claim 1, wherein the offset information includes a path-length difference between the first signal and the second signal.

5. The apparatus according to claim 4, wherein the system is further configured to control an initial range of the path-length difference.

6. The apparatus according to claim 5, wherein the range is modulo a wavelength of the path-length difference.

7. The apparatus according to claim 4, wherein the path-length difference is an optical path-length difference.

8. The apparatus according to claim 7, further comprising an arrangement configured to receive the offset information, and control the path-length difference over a further range that is longer than an initial range.

9. The apparatus according to claim 1, wherein the phase is controlled by modifying a path-length difference between the first signal and the second signal.

10. The apparatus according to claim 9, wherein the path-length difference is an optical path-length difference.

11. The apparatus according to claim 1, wherein the second information includes a phase-stabilized signal which is associated with the interference signal.

12. The apparatus according to claim 1, wherein the second information includes a signal which has a signal-to-noise ratio which is greater than a signal-to-noise ratio of the interference signal obtained before the phase is controlled.

13. The apparatus according to claim 1, wherein the system includes at least one detector array which detects the at least one interference signal.

14. The apparatus according to claim 1, wherein the reference is at least one of a non-reflective reference or a transmissive reference.

15. A method for controlling a phase of a signal, comprising:

(a) obtaining at least one interference signal which is based on a first signal from a sample and a second signal from a reference;

(b) during step (a), modulating the phase of the at least one interference signal to produce first information;

(c) determining offset information between the first signal and the second signal based on the first information;

(d) using a computing arrangement, controlling the phase of the at least one interference signal using the offset information to generate second information; and

(e) using the computing arrangement, generating an image which includes a plurality of depth profiles of at least a portion of the sample using the second information.

16. The method according to claim 15, wherein the first information includes a modulated interference signal.

17. The method according to claim 15, further comprising the step of demodulating the first information using at least one periodic signal, wherein the offset information is determined based on the demodulated first information.

18. The method according to claim 15, wherein the offset information includes a path-length difference between the first signal and the second signal.

19. The method according to claim 18, wherein the path-length difference is an optical path-length difference.

20. The method according to claim 15, further comprising the step of controlling an initial range of the path-length difference.

21. The method according to claim 15, wherein the range is modulo a wavelength of the path-length difference.

22. The method according to claim 15, wherein step (c) is performed by modifying a path-length difference between the first signal and the second signal.

23. The method according to claim 22, wherein the path-length difference is an optical path-length difference.

24. The method according to claim 15, wherein the second information includes a phase-stabilized signal which is associated with the interference signal.

25. The method according to claim 15, wherein the second information includes a signal which has a signal-to-noise ratio which is greater than a signal-to-noise ratio of the interference signal obtained before the phase is controlled.

26. The method according to claim 15, further comprising an arrangement configured to receive the offset information, and control the path-length difference over a further range that is longer than an initial range.

27. The method according to claim 15, wherein the reference is at least one of a non-reflective reference or a transmissive reference.