Magnetic breather pump and a method for treating a brain tumor using the same

• US 7,799,016 B2
• Filed: 06/20/2008
• Issued: 09/21/2010
• Est. Priority Date: 06/20/2008
• Status: Active Grant

• Current Assignee: Neuro-Kinesis Corporation
• Original Assignee: Pharmaco Kinesis Corporation
• Inventors: Chen, Thomas C., Johnson, David, Shachar, Yehoshua, Farkas, Laszlo, Farkas, Leslie, Marx, Bruce
• Primary Examiner(s): Sirmons; Kevin C
• Assistant Examiner(s): WILSON, LARRY ROSS
• Application Number:
  US12/143,720
• Publication Number:
  US 20090318902A1
• Time in Patent Office: 823 Days
• Field of Search: 604 65- 67, 604/101.01, 604/101.02, 604/103.01, 604/103.02, 604/131, 604151-155, 604257-258, 604/508, 604/890.1, 604/891.1, 604/892.1, 604/97.01, 604/97.02, 604/506, 604/507, 604/509, 222/105, 222/207, 222/386.5, 222/527
• US Class Current: 604/891.1
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

A magnetically controlled pump is implanted into the brain of a patient and delivers a plurality of medicating agents at a controlled rate corresponding to the specific needs of the patient. The current invention comprises a flexible double walled pouch that is formed from two layers of polymer. The pouch is alternately expanded and contracting by magnetic solenoid. When contracted, a medicating agent is pushed out of the pouch through a plurality of needles. When the pouch is expanded, surrounding cerebral fluid is drawn into the space between the double walls of the pouch from which it is drawn through a catheter to an analyzer. Cerebral fluid drawn from the patient is analyzed. The operation of the apparatus and hence the treatment is remotely controlled based on these measurements and displayed through an external controller.

Claims

1. An apparatus for delivering medicating agents directly to the brain of a patient comprising;

a magnetically operated cranium delivery pump disposable in the brain at a treatment site;

a fluid exchange catheter coupled to the cranium delivery pump;

a subdermally implantable chemotherapy pump device (CPD) coupled to the fluid exchange catheter;

an external controller communicated to the CPD by means of an RF the external controller capable of altering a delivery schedule of medicating agents to the brain of the patient by the cranium delivery pump based on measurements of a plurality of tumor parameters obtained from the cranium delivery pump and quantified by the CPD; and

a display coupled to the external controller,

wherein the magnetically operated cranium delivery pump further comprises a head portion and a base portion and wherein an magnetic actuator is coupled to each said head and base portions of the pump, the surface of the head and base portions of the pump being coupled within each respective end of the magnetic actuator,

wherein the magnetic actuator operates to alternate the cranium delivery pump between a contracted configuration and an expanded configuration to provide a pump cycle, and

wherein the magnetic actuator further comprises an oscillating electromagnetic solenoid, an internal drug inlet fluidly coupled to a medicating agent reservoir, and an internal sampling fluid outlet fluidly coupled to a intra-membrane reservoir.

2. The apparatus of claim 1 where the cranium delivery pump is comprised of an inner membrane defining the medicating agent reservoir and an outer membrane enclosing the inner membrane to define the intra-membrane reservoir between the inner and outer membrane, and where the medicating agent reservoir and the intra-membrane reservoir are configured so that they are not in fluid communication with one another.

3. The apparatus of claim 2 where the inner membrane further comprises a plurality of hollow needles coupled to the inner layer, said hollow needles extending through the outer membrane of the cranium delivery pump and the intra-membrane reservoir defined there between when in the contracted configuration.

4. The apparatus of claim 3 where the outer membrane further comprises a plurality of pores defined within the surface of the outer membrane and around each of the plurality of hollow needles coupled to the inner membrane, said pores through which surrounding cerebral fluid from the patient is drawn into the intra-membrane reservoir of the cranium delivery pump at a variable rate.

5. The apparatus of claim 2 further comprising a shunt coupled to the head portion of the cranium delivery pump, the shunt including a refill line and a return line coupled to the medicating agent reservoir and the intra-membrane reservoir respectively.

6. The apparatus of claim 1 where the CPD comprises:

a pump electronics assembly;

at least one medicating agent ampoule fluidicly communicated to the pump electronics assembly;

a induction charger electronics assembly; and

at least one electronics interconnect cable coupling the pump electronics assembly and induction charger electronics assembly together.

7. The apparatus of claim 6 where the pump electronics assembly further comprises:

a drug delivery CPU;

a lab-on-a-chip coupled to the drug delivery CPU;

at least four ampoule pump driver chips coupled to the drug delivery CPU;

a return pump controller chip coupled to the drug delivery CPU;

a delivery valve integrated circuit coupled to the drug delivery CPU; and

at least two flash memory chips coupled to the drug delivery CPU.

8. The apparatus of claim 7 further comprising a plurality of piezoelectric pumps and a delivery valve, and where each of the ampoule pump driver chips are coupled to a corresponding piezoelectric pump which is fluidicly coupled to the delivery valve.

9. The apparatus of claim 8 further comprising a return piezoelectric pump and where the return pump controller chip is coupled to the return piezoelectric pump which is fluidicly coupled to the delivery valve.

10. The apparatus of claim 9 where the delivery valve integrated circuit is coupled to the delivery valve.

11. The apparatus of claim 6 further comprising a Bluetooth®

transceiver and antenna.

12. The apparatus of claim 6 further comprising at least four different medicating agent ampoules.