Needle-to-needle electrospinning

• US 7,799,261 B2
• Filed: 11/20/2008
• Issued: 09/21/2010
• Est. Priority Date: 11/30/2007
• Status: Active Grant

• Current Assignee: Cook Medical Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated), Med Institute
• Inventors: Orr, David E., Moore, William F.
• Primary Examiner(s): Johnson; Christina
• Assistant Examiner(s): Hauth; Galen
• Application Number:
  US12/274,530
• Publication Number:
  US 20090142505A1
• Time in Patent Office: 670 Days
• Field of Search: 264/441, 427/471, 118/621, 118/622
• US Class Current: 264/441
• CPC Class Codes: B05B 5/0255 spraying and depositing by electrostatic forces only
• CPC Class Codes: B05B 5/08 Plant for applying liquids or other fluent materials to objects
• CPC Class Codes: B05B 5/087 Arrangements of electrodes, e.g. of charging, shielding, collecting electrodes B05B5/12, B05B5/14 take precedence; arrangements of electrodes on the discharge apparatus B05B5/0533
• CPC Class Codes: B05B 5/12 specially adapted for coating the interior of hollow bodies
• CPC Class Codes: B05D 1/04 involving the use of an electrostatic field B05D1/025 and B05D1/14 take precedence
• CPC Class Codes: B05D 2252/10 Applying the material on both sides
• CPC Class Codes: B05D 2254/02 Applying the material on the exterior of the tube
• CPC Class Codes: B05D 2254/04 Applying the material on the interior of the tube
• CPC Class Codes: D01D 5/0061 characterised by the electro-spinning apparatus
• CPC Class Codes: D01D 5/0084 Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses

Abstract

The disclosure relates to a method and apparatus for coating a medical device. The method includes providing an electrospinning apparatus and simultaneously electrospinning at least one solution onto a first surface and an opposing second surface. The apparatus comprises a first spinneret and a second spinneret. An energy source is electrically coupled to the first spinneret and the second spinneret. The first spinneret and second spinneret comprise a reservoir and an orifice fluidly coupled to the reservoir. The first spinneret orifice is located substantially opposite the second spinneret orifice.

Claims

1. A method for preparing a medical device comprising:

providing a medical device and an electrospinning apparatus;

the medical device defining a lumen with a proximal end, a distal end, a luminal surface, and an abluminal surface;

the electrospinning apparatus comprising a first spinneret and a second spinneret;

the first spinneret comprising a reservoir loaded with a first solution and an orifice, the first spinneret orifice comprising a proximal end fluidly coupled to the reservoir and a distal end through which the first solution is electrospun;

the second spinneret comprising a reservoir loaded with a second solution and an orifice, the second spinneret orifice comprising a proximal end fluidly coupled to the reservoir and a distal end through which the second solution is electrospun;

locating the first spinneret orifice distal end outside of the medical device lumen between the medical device proximal end and the medical device distal end and between about 0.1 inches and about 6.0 inches from the medical device abluminal surface, the first spinneret orifice distal end directly facing the medical device abluminal surface;

locating the second spinneret orifice distal end in the medical device lumen between the medical device proximal end and the medical device distal end and between about 0.1 inches and 2.0 inches from the medical device luminal surface, the second spinneret orifice distal end directly facing the medical device luminal surface;

further locating the first spinneret orifice distal end and the second spinneret orifice distal end opposite one another;

simultaneously electrospinning the first solution onto the medical device abluminal surface and the second solution onto the medical device luminal surface.

2. The method of claim 1 where the electrospinning apparatus further comprises an energy source electrically coupled to the first spinneret and the second spinneret and further comprising applying a first electrical charge with the energy source to the first spinneret and applying a second, opposing electrical charge with the energy source to the second spinneret.

3. The method of claim 1, where the first solution and second solution comprise at least one material selected from the group comprising polymers, proteins, bioadhesives, and bioactive agents.

4. The method of claim 3, where the first solution is different from the second solution.

5. The method of claim 1, further comprising moving the medical device relative the first spinneret orifice distal end or second spinneret orifice distal end and simultaneously electrospinning the first solution about a length or width of the medical device abluminal surface and the second solution about a length or width of the medical device luminal surface.