Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents

• US 7,799,339 B2
• Filed: 04/30/2008
• Issued: 09/21/2010
• Est. Priority Date: 04/30/2007
• Status: Active Grant

• Current Assignee: Intezyne Technologies
• Original Assignee: Intezyne Technologies
• Inventors: Skaff, Habib, Breitenkamp, Kurt, Sill, Kevin N.
• Primary Examiner(s): Krass; Frederick
• Assistant Examiner(s): Shomer; Isaac
• Application Number:
  US12/112,825
• Publication Number:
  US 20080274173A1
• Time in Patent Office: 874 Days
• Field of Search: None
• US Class Current: 424/450
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C08G 2261/126 block
• CPC Class Codes: C08G 65/2627 containing aromatic or arylaliphatic amine groups
• CPC Class Codes: C08G 65/325 containing nitrogen
• CPC Class Codes: C08G 65/33341 aromatic
• CPC Class Codes: C08G 69/08 derived from amino-carboxylic acids
• CPC Class Codes: C08G 73/028 Polyamidoamines
• CPC Class Codes: C08J 2377/04 Polyamides derived from alpha-amino carboxylic acids C08J2377/10 takes precedence
• CPC Class Codes: C08J 3/03 in aqueous media
• CPC Class Codes: C08L 2203/02 for biomedical use
• CPC Class Codes: Y10S 930/29 Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/906 Drug delivery

Abstract

The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

Claims

1. A triblock copolymer of the following structure: