Nanoparticle structures comprising silicon oxide-based polymer, and composite materials

• US 7,799,426 B2
• Filed: 11/07/2008
• Issued: 09/21/2010
• Est. Priority Date: 12/23/2005
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Atanasoska, Liliana L., Warner, Robert W., Ippoliti, J. Thomas, Schewe, Scott R.
• Primary Examiner(s): Le; H. (Holly) T
• Application Number:
  US12/266,984
• Publication Number:
  US 20090062483A1
• Time in Patent Office: 683 Days
• Field of Search: 428/403, 428/447, 428/448, 977/778, 977/783
• US Class Current: 428/403
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 5/005 Reinforced macromolecular compounds with nanosized materials, e.g. nanoparticles, nanofibres, nanotubes, nanowires, nanorods or nanolayered materials
• CPC Class Codes: C08K 9/04 Ingredients treated with organic substances treated with macromolecular compounds C08K9/08
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/778 within specified host or matrix material, e.g. nanocomposite films
• CPC Class Codes: Y10S 977/783 Organic host/matrix, e.g. lipid
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2993 Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.

Claims

1. A nanoparticle comprising a silicon-oxide based core of a polymer with an organic compound that extends from the core, where the silicon-oxide based polymer is formed using a sol-gel process, and the organic compound has a chemical linkage moiety that is selected to form a non-covalent bond to link a portion of the silicon-oxide based polymer.

2. The nanoparticle of claim 1, where the silicon-oxide based polymer of the core is formed using a nanoparticle precursor structure of the formula (R₁O)_wSi(R₂-A-R)_z and at least one silicon alkoxide of the formula Si(OR₃)₄ in the sol-gel process, where A is the chemical linkage moiety that is selected to form the non-covalent bond, R, R₁, R₂ and R₃ are each independently an organic group, and w and z are each independently 1 to 3.

3. The nanoparticle of claim 2, where each R, R₁ and R₃ is independently a (C2-C18)alkyl group, and R₂ is a (C2-C18)alkylene group.

4. The nanoparticle of claim 2, where A is a urethane group.

5. The nanoparticle of claim 2, where A is a urea group.

6. The nanoparticle of claim 5, where R is a (C2-C8)alkyl group and R₂ is a (C2-C18)alkylene group.

7. The nanoparticle of claim 1, where the nanoparticle includes a compound of the formula [(Si—

O)_n—

(Si—

O)_m]_p—

(R₂-A-R)_r;

where A is the chemical linkage moiety that is selected to form a non-covalent bond to link the portion of the polymer, R and R₂ are each independently an organic group;

n, m and p are each independently in a polymeric range; and

r is at least 25 percent of n.

8. A composite material, comprising:

a polymer having non-covalent bonding groups; and

a nanoparticle dispersed in the polymer, where the nanoparticle includes a silicon-oxide based core of the polymer with an organic compound that extends from the core, where the silicon-oxide based polymer is formed using a sol-gel process, and the organic compound has a chemical linkage moiety that is selected to form a non-covalent bond to link a portion of the silicon-oxide based polymer.

9. The composite material of claim 8, where the silicon-oxide based core of the polymer is formed using a nanoparticle precursor structure of the formula (R₁O)_wSi(R₂-A-R)_z and at least one silicon alkoxide of the formula Si(OR₃)₄ in the sol-gel process, where A is the chemical linkage moiety that is selected to form the non-covalent bond R, R₁, R₂ and R₃ are each independently an organic group, and w and z are each independently 1 to 3.

10. The composite material of claim 9, where A is a urethane group.

11. The composite material of claim 9, where A is a urea group.

12. The composite material of claim 9, where each R, R₁, and R₃ is independently a (C2-C8)alkyl group, and R₂ is a (C2-C18)alkylene group.