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Albumin fusion proteins

  • US 7,799,759 B2
  • Filed: 07/02/2007
  • Issued: 09/21/2010
  • Est. Priority Date: 12/21/2001
  • Status: Expired due to Fees
First Claim
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1. A method of extending the shelf life of GLP-1 polypeptides, comprising the step of fusing two or more GLP-1 polypeptides to albumin comprising the amino acid sequence of SEQ ID NO:

  • 1038, albumin fragment, or albumin variant thereof, and producing the albumin fusion protein, wherein said albumin fusion protein is sufficient to extend the shelf-life of the GLP-1 polypeptides compared to the shelf-life of the GLP-1 polypeptides in an unfused state, wherein said GLP-1 polypeptides are selected from wild-type GLP-1, GLP-1 fragments, and GLP-1 variants, and wherein the albumin fusion protein has GLP-1 activity, and further wherein the two or more GLP-1 polypeptides are fused at the N-terminus and/or the C-terminus of albumin.

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