Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor
First Claim
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1. A method for treating at least one of a digestive cancer and a breast cancer, comprisingorally administering a composition comprising α
- ,α
,α
-trifluorothymidine (FTD) and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1;
0.5 at a dose of 50 to 70 mg/m2/day in terms of FTD in 2 or 3 divided portions per day to a human patient in need of treatment of at least one of a digestive cancer and a breast cancer,wherein the administration of a daily dose of said composition is in 2 or 3 portions per day for 5 days followed by 2 days off treatment in the week on a one-week dosing schedule.
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Abstract
The present invention relates to a method for treating a cancer comprising orally administering a composition containing α,α,α-trifluorothymidine (FTD) and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1:0.5 at a dose of 20 to 80 mg/m2/day in terms of FTD in 2 to 4 divided portions per to patients in need of the treatment.
17 Citations
12 Claims
-
1. A method for treating at least one of a digestive cancer and a breast cancer, comprising
orally administering a composition comprising α - ,α
,α
-trifluorothymidine (FTD) and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1;
0.5 at a dose of 50 to 70 mg/m2/day in terms of FTD in 2 or 3 divided portions per day to a human patient in need of treatment of at least one of a digestive cancer and a breast cancer,wherein the administration of a daily dose of said composition is in 2 or 3 portions per day for 5 days followed by 2 days off treatment in the week on a one-week dosing schedule. - View Dependent Claims (2, 7, 10)
- ,α
-
3. A method for treating at least one of a digestive cancer and a breast cancer, comprising
orally administering a composition comprising α - ,α
,α
-trifluorothymidine (FTD) and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1;
0.5 at a dose of 50 to 70 mg/m2/day in terms of FTD in 2 or 3 divided portions per day to a human patient in need of treatment of at least one of a digestive cancer and a breast cancer,wherein the α
,α
,α
-trifluorothymidine incorporated into the target site DNA of the cancer one day after the oral administration is present in an amount that is at least a factor of 1.72 greater than the amount of α
,α
,α
-trifluorothymidine incorporated into the target site DNA of the cancer after an equal amount of α
,α
,α
-trifluorothymidine is orally administered in a single dose after one day. - View Dependent Claims (5, 8, 11)
- ,α
-
4. A method for treating at least one of a digestive cancer and a breast cancer, comprising:
-
orally administering a composition comprising α
,α
,α
-trifluorothymidine and 5-chloro-6-(1-(2-iminopyrrolidinyl)methyl)uracil hydrochloride in a molar ratio of 1;
0.5 at a dose of 50 to 70 mg/m2/day in terms of α
,α
,α
-trifluorothymidine in 2 or 3 divided portions per day to a human patient in need of treatment of at least one of a digestive cancer and a breast cancer,wherein the α
,α
,α
-trifluorothymidine incorporated into the target site DNA of the cancer after three days of orally administering the α
,α
,α
-trifluorothymidine is present in an amount that is at least a factor of 1.69 greater than the amount of the α
,α
,α
-trifluorothymidine incorporated into the target site DNA when the oral administration is carried out in a single dose for three days. - View Dependent Claims (6, 9, 12)
-
Specification