Extravasation detector

• US 7,801,583 B2
• Filed: 12/10/2003
• Issued: 09/21/2010
• Est. Priority Date: 12/10/2002
• Status: Active Grant

• Current Assignee: Respinor As
• Original Assignee: Neorad AS
• Inventors: Brabrand, Knut
• Primary Examiner(s): Le; Long V
• Assistant Examiner(s): Cattungal; Sanjay
• Application Number:
  US10/730,919
• Publication Number:
  US 20040176690A1
• Time in Patent Office: 2,477 Days
• Field of Search: 600437-456, 600/464, 600500-504, 600/507, 600/407, 600/425, 600/547, 600/382, 600/384, 600/393, 604/65, 604/66, 604/253, 604/272, 604/503, 604/900, 382/131
• US Class Current: 600/382
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066

Abstract

Ultrasound Doppler probe 2 is placed above the vein downstream of the infusion site. Processor 4 converts the output from the probe 2 into a form that may be displayed as an image on display unit 5. It also determines whether the velocity corresponds to a flow of contrast medium along the vein. If the cannula 13 is properly sited and the contrast medium flows as desired along the vein, this will lead to an increased flow velocity in the vein. This is detected by ultrasound probe 2 and, as described above, the processor unit 4 will therefore determine that no extravasation has occurred. However, where extravasation of contrast medium occurs this results in a low or zero velocity output from the probe 2 from which the processor unit 4 determines that extravasation has occurred. It therefore immediately sends a “stop” signal to pump controller 11 which stops pump 10.

Claims

1. A method of detecting extravasation during a procedure infusing a substance into a blood vessel, comprising the steps of infusing a substance into the blood vessel;

generating a first signal proportional to a flow velocity within the blood vessel downstream of the point of infusion, at a first time;

generating a second signal proportional to the flow velocity within the blood vessel downstream of the point of infusion, at a second time;

generating a third signal representing an increase in flow velocity, based on the first and second signals; and

generating a fourth signal indicating extravasation if an increase in flow velocity represented by the third signal is less than a threshold value.

2. A method as claimed in claim 1, wherein an array of detector elements is arranged substantially transverse to the direction of flow of the blood vessel downstream of the point of infusion so as to locate at least one of said array of detector elements over the vessel.

3. A method as claimed in claim 1 or 2, wherein the flow velocity within the blood vessel is measured at a plurality of points spaced apart along the vessel and downstream of the point of infusion.

4. A method as claimed in claim 1, wherein the infusion is a venous infusion of a contrast agent.

5. A method as claimed in claim 1, wherein a change in the flow velocity is continuously or repeatedly monitored.

6. A method as claimed in claim 1, further comprising the provision of a notification that extravasation has occurred.

7. A method as claimed in claim 1, further comprising an automatic shutdown of the infusion in response to the detection of extravasation.

8. A method as claimed in claim 1, wherein extravasation is indicated by a lack of velocity increase after the intended infusion has commenced.

9. A method as claimed in claim 2, wherein the detector elements are ultrasound transducer elements.

10. An apparatus for detecting extravasation during an intended infusion of a substance into a blood vessel at a point of infusion, comprising:

a detector for generating a flow signal corresponding to a flow velocity within the blood vessel downstream of the point of infusion; and

a controller coupled to the detector and configured to;

determine a first flow velocity at a first time based on the flow signal;

determine a second flow velocity at a second time during infusion based on the flow signal; and

generate an output signal indicating occurrence of extravasation based on the difference between the first flow velocity and the second flow velocity.

11. An apparatus as claimed in claim 10, wherein the detector comprises an array of detector elements that are arranged substantially transverse to the direction of flow of the blood vessel so as to locate at least one of said array of detector elements over the vessel.

12. An apparatus as claimed in claim 10 or 11, wherein the detector measures the flow velocity within the blood vessel at a plurality of points spaced apart along the vessel and downstream of the point of infusion.

13. An apparatus as claimed in claim 10, wherein the output signal is a notification or alarm.

14. An apparatus as claimed in claim 10, wherein the output signal is a control signal to control the infusion.

15. An apparatus as claimed in claim 10, wherein the detector is an ultrasound Doppler probe.

16. An apparatus as claimed in claim 11, wherein the detector elements are ultrasound transducer elements.

17. A system for giving an infusion comprising an infusion pump arranged to infuse a substance into a blood vessel and an extravasation detector according to claim 10, wherein the detector apparatus is arranged to control the infusion pump.

18. An apparatus as claimed in claim 10, wherein the apparatus is arranged to provide an output signal when there is a lack of velocity increase after the intended infusion has commenced.