Stimulus regimens for cardiovascular reflex control

• US 7,801,614 B2
• Filed: 10/23/2006
• Issued: 09/21/2010
• Est. Priority Date: 09/27/2000
• Status: Expired due to Term

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Persson, Bruce J., Serdar, David J., Rossing, Martin A., Kieval, Robert S.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): Heller; Tammie K
• Application Number:
  US11/552,005
• Publication Number:
  US 20070049989A1
• Time in Patent Office: 1,429 Days
• Field of Search: 607/44, 607 68- 70, 607 72- 74, 607/59
• US Class Current: 607/44
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.

Claims

1. A method of treating a patient with a baroreflex activation device, the method comprising:

establishing a series of therapy intervals;

establishing a plurality of burst intervals during at least one of the therapy intervals;

wherein the burst intervals are commensurate with an interval between heartbeats of the patient;

generating an electrical output signal, based on the series of therapy intervals, characterized in that electrical power applied to the activation device has a time dependence;

wherein at least one of the therapy intervals has a first portion characterized by an average electrical power, referred to as a first therapy portion average power, and a second portion characterized by an average electrical power, referred to as a second therapy portion average power, the first therapy portion average power being different from the second therapy portion average power, and wherein at least one of the burst intervals has a first portion characterized by an average electrical power, referred to as a first burst portion average power, and a second portion characterized by an average electrical power, referred to as a second burst portion average power, the first burst portion average power being different from the second burst portion average power.

2. The method of claim 1 wherein generating the electrical output signal comprises generating electrical pulses having one or more pulse characteristics chosen to provide said time dependence of electrical power applied to the activation device.

3. The method of claim 2 wherein said pulse characteristics include one or more of pulse amplitude, pulse width, pulse frequency, pulse separation, pulse waveform, pulse polarity, and pulse phase.