Methods and apparatus for intraocular brachytherapy

• US 7,803,102 B2
• Filed: 11/07/2006
• Issued: 09/28/2010
• Est. Priority Date: 02/12/2004
• Status: Expired due to Fees

• Current Assignee: Oraya Therapeutics, Inc.
• Original Assignee: Neovista, Inc.
• Inventors: Fritz, Eberhard, Pintaske, Rainer, Willenkamp, Sabine, Phillipps, Gerd T., Larsen, Charles E., Trip, Roelof, Hillstead, Richard A., Humayun, Mark S., deJuan, Eugene
• Primary Examiner(s): Marmor, II; Charles A
• Assistant Examiner(s): MATTHEWS, CHRISTINE HOPKINS
• Application Number:
  US11/593,683
• Publication Number:
  US 20070055089A1
• Time in Patent Office: 1,421 Days
• Field of Search: 600 1- 8, 378/119
• US Class Current: 600/3
• CPC Class Codes: A61N 5/1017 Treatment of the eye, e.g. for "macular degeneration"

Abstract

A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

Claims

1. A device for local, directional delivery of radiation to intraocular target tissue comprising:

a radiation source;

a substantially rigid cannula sized for intraocular insertion into an eye and having a proximal end and a distal end for receiving the radiation source comprising a tubular member with at least one lumen and having a radiation window at its distal end for providing a desired radiation dose profile when the radiation source is received therein, the distal end of the cannula including a cover covering the window with a fluid tight seal so as to prevent contact of body fluids with the radiation source; and

a housing to which the proximal end of the cannula is secured for moving the radiation source within the lumen of the cannula between a retracted proximal position interior of the housing and a treatment position at the distal end of the cannula, the housing comprising an advancement mechanism operatively coupled to the radiation source, the advancement mechanism being movable to move the radiation source between the retracted position and the treatment position.

2. The radiation delivery device of claim 1 wherein the housing comprises a shielding zone for shielding the radiation source in the retracted position.

3. The radiation delivery device of claim 1 wherein the housing provides a positive visual indication of the retracted and treatment positions of the radiation source.

4. The radiation delivery device of claim 1 wherein the advancement mechanism is lockable in the retracted position.

5. The radiation delivery device of claim 1 wherein the housing includes an elongated slot having first and second ends through a surface thereof and the advancement mechanism can be manipulated through the slot so that the radiation source can be moved between the retracted and treatment positions.

6. The radiation delivery device of claim 1 wherein the radiation source emits ionizing radiation.

7. The radiation delivery device of claim 1 wherein the distal end of the radiation source is sufficiently flexible to allow unimpeded mechanical transport through the cannula around a radius of curvature of from 4 to 8 mm.

8. The radiation delivery device of claim 1 wherein the radiation source is radioactive and the device further comprises a source delivery wire attached to the radioactive source, wherein the source delivery wire has proximal and distal ends and wherein the proximal end and the distal end of the radioactive source wire comprise steel braided wire with a connection therebetween, and a sleeve for reinforcing the connection of the proximal end to the distal end.

9. The radiation delivery device of claim 1 wherein the radioactive source emits beta radiation.

10. The radiation delivery device of claim 1 wherein the window comprises a tip of a platinum-iridium material.

11. The device of claim 1 further comprising a separate lumen associated with the cannula having an opening adjacent the distal end of the cannula, a wire having a distal end that is slidingly received in the lumen, and an expandable structure at the distal end of the wire, the structure expanding as the distal end of wire exits the opening of the lumen.

12. The device of claim 1 wherein the cannula further comprises at least one inflatable balloon located at the distal end thereof, and a separate lumen for selectively inflating and deflating the balloon.

13. The device of claim 1 wherein the cannula further comprises a separate lumen having an opening at the distal end of the cannula through which fluid may be selectively administered or withdrawn.

14. A device for local, directional delivery of radiation to intraocular target tissue comprising:

a radioactive radiation source attached to a source delivery wire, the source delivery wire having proximal and distal ends and wherein the proximal end and the distal end of the radioactive source wire comprise steel braided wire with a connection therebetween, and a reinforcing member for securing the proximal end to the distal end;

a substantially rigid cannula sized for intraocular insertion into an eye and having a proximal end and a distal end for receiving the radiation source, the cannula being fluid tight so as to prevent contact of body fluids with the radiation source; and

a housing to which the proximal end of the cannula is secured for moving the radiation source between a retracted proximal position interior of the housing and a treatment position at the distal end of the cannula, the housing comprising an advancement mechanism operatively coupled to the radiation source, the advancement mechanism being movable to move the radiation source between the retracted position and the treatment position.