Stable hydroalcoholic compositions
DCFirst Claim
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1. A hydroalcoholic skin disinfection composition comprising:
- a) a lower alcohol and water in a weight ratio of about 35;
65 to about 95;
5;
b) at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition; and
c) at least one emollient;
wherein at least one emollient is a humectant, at least one emollient is a wax at room temperature and is a soluble species in the solvent phase; and
further wherein at least one emollient is a polyether/polysiloxane copolymer surfactant having the following chemical structure;
(CH3)3—
Si—
O—
[Si(CH3)R11—
O]x[Si(CH3)R8—
O]y—
Si(CH3)3 where x+y=5-400, preferably 15-200, andR8 is a polyether substituted alkyl group with the structure;
—
R9—
O(C2H4O)p(C3H6O)qR10;
where R9 is an alkyl group of 1 to 6 carbon atoms;
R10 is hydrogen or an alky group of 1-22 carbon atoms;
R11 is an alkyl group of 1 to 22 carbon atoms or phenyl;
p=2-300, preferably 8-100; and
q=0-100d) an antimicrobial agent distinct from the lower alcohol.
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Abstract
A hydroalcoholic lotion is disclosed which comprises (a) a lower alcohol and water in a weight ratio of about 35:65 to 100:0, and (b) between at least 0.5% and 8% by weight thickener system comprised of at least one emulsifier present in at least 0.05% by weight wherein the composition in a polymer free state has a viscosity of at least 4,000 centipoise at 23 degrees C. and wherein the emulsifier is comprised of at least one hydrophobic group and at least one hydrophilic group. The hydroalcoholic composition is useful as a hand preparation such as a lotion or as a presurgical scrub replacement.
158 Citations
70 Claims
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1. A hydroalcoholic skin disinfection composition comprising:
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a) a lower alcohol and water in a weight ratio of about 35;
65 to about 95;
5;b) at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition; and c) at least one emollient; wherein at least one emollient is a humectant, at least one emollient is a wax at room temperature and is a soluble species in the solvent phase; and
further wherein at least one emollient is a polyether/polysiloxane copolymer surfactant having the following chemical structure;
(CH3)3—
Si—
O—
[Si(CH3)R11—
O]x[Si(CH3)R8—
O]y—
Si(CH3)3where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure;
—
R9—
O(C2H4O)p(C3H6O)qR10;where R9 is an alkyl group of 1 to 6 carbon atoms; R10 is hydrogen or an alky group of 1-22 carbon atoms; R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100 d) an antimicrobial agent distinct from the lower alcohol. - View Dependent Claims (2, 3)
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4. A composition comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 100;
0;b) an antimicrobial agent selected from the group consisting of a chlorhexidine salt, parachlorometaxylenol, triclosan, Lauricidin, a phenol, hydrogen peroxide, silver, a silver salt, and a mixture thereof and c) at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein the emulsifier comprises;(i) at least one hydrophobic group selected from the group of; (A) an alkyl group of at least 24 carbon atoms; (B) an alkenyl group of at least 24 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 24 carbon atoms; and (ii) at least one hydrophilic group selected from the group of; (A) an ethylene oxide- and/or propylene oxide-containing group bonded to the hydrophobic group through an ether or ester bond and optionally terminated with a (C1-C36)alkyl ester, (C2-C36)alkenyl ester, or (C6-C36)alkaryl ester; (B) an alcohol group; (C) a polyhydric alcohol group; (D) an ester or ether group of a polyhydric alcohol or polyalkoxylated derivative thereof (E) an ester or ether group of sorbitan or polyalkoxylated derivative thereof having 2-150 moles of alkylene oxide per mole of hydrophobic group; and (F) combinations thereof. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11)
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12. A hydroalcoholic composition comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 75;
25;b) an antimicrobial agent selected from the group consisting of a chlorhexidine salt, parachlorometaxylenol, triclosan, Lauricidin, a phenol, hydrogen peroxide, silver, a silver salt, and a mixture thereof and c) an emulsifier system comprised of at least one emulsifier in an amount of at least about 0.05% by weight, based on the total weight of the composition;
wherein the emulsifier comprises;(i) at least one hydrophobic group selected from the group of; (A) an alkyl group of at least 16 carbon atoms; (B) an alkenyl group of at least 16 carbon atoms; and (C) an aralkyl or an aralkenyl group of at least 20 carbon atoms; and (ii) at least one hydrophilic group selected from the group of; (A) an ethylene oxide- and/or propylene oxide-containing group bonded to the hydrophobic group through an ether or ester bond and optionally terminated with a (C1-C36)alkyl ester, (C2-C36)alkenyl ester, or (C6-C36)alkaryl ester; (B) an alcohol group; (C) a polyhydric alcohol group; (D) an ester or ether group of a polyhydric alcohol or polyalkoxylated derivative thereof; (E) an ester or ether group of sorbitan or polyalkoxylated derivative thereof having 2-150 moles of alkylene oxide per mole of hydrophobic group; and (F) combinations thereof; wherein; the emulsifier system has a weight average hydrophile/lipophile balance of about 4 to about 16; the composition has a melt temperature of greater than about 35°
C.; and
the composition is stable. - View Dependent Claims (13, 14, 15, 16, 17, 18)
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19. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;b) an emulsifier comprising at least one long chain hydrocarbon of at least 22 carbon atoms; and c) an emollients, wherein the emollient is a polyether/polysiloxane copolymer having the following chemical structure;
(CH3)3—
Si—
O—
[Si(CH3)R11—
O]x[Si(CH3)R8—
O]y—
Si(CH3)3where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure;
—
R9—
O(C2H4O)p(C3H6O)qR10;where R9 is an alkyl group of 1 to 6 carbon atoms R10 is hydrogen or an alky group of 1-22 carbon atoms R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;
wherein the lower alcohol is present in the hydroalcoholic foam in an amount of at least 47.7 wt-%;b) a polyethoxylated emulsifier comprising at least one long chain hydrocarbon of at least 18 carbon atoms; and c) an emollient, wherein the emollient is a polyether/polysiloxane copolymer having the following chemical structure;
(CH3)3—
Si—
O—
[Si(CH3)R11—
O]x[Si(CH3)R8—
O]y—
Si(CH3)3where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure;
—
R9—
O(C2H4O)p(C3H6O)qR10;where R9 is an alkyl group of 1 to 6 carbon atoms R10 is hydrogen or an alky group of 1-22 carbon atoms R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;b) an emulsifier comprising at least one long chain hydrocarbon of at least 22 carbon atoms; and c) an emollient, wherein the emollient is a dialkoxy dimethicone having the following chemical structure;
R—
O—
Si(CH3)2—
O[Si(CH3)2—
O]z—
Si(CH3)2—
ORwhere R is a straight chain alkyl group of 14-50, and z=5-300. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;
wherein the lower alcohol is present in the hydroalcoholic foam in an amount of at least 47.7 wt-%;b) a polyethoxylated emulsifier comprising at least one long chain hydrocarbon of at least 18 carbon atoms; and c) an emollient, wherein the emollient is a dialkoxy dimethicone having the following chemical structure;
R—
O—
Si(CH3)2—
O[Si(CH3)2—
O]z—
Si(CH3)2—
ORwhere R is a straight chain alkyl group of 14-50, and z=5-300. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;
wherein the lower alcohol is present in the hydroalcoholic foam in an amount of at least 60 wt-%;b) a polyethoxylated emulsifier; and c) an emollient, wherein the emollient is a polyether/polysiloxane copolymer having the following chemical structure;
(CH3)3—
Si—
O—
[Si(CH3)R11—
O]x[Si(CH3)R8—
O]y—
Si(CH3)3where x+y=5-400, preferably 15-200, and R8 is a polyether substituted alkyl group with the structure;
—
R9—
O(C2H4O)p(C3H6O)qR10;where R9 is an alkyl group of 1 to 6 carbon atoms; R10 is hydrogen or an alky group of 1-22 carbon atoms; R11 is an alkyl group of 1 to 22 carbon atoms or phenyl; p=2-300, preferably 8-100; and q=0-100.
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70. A hydroalcoholic foam comprising:
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a) a hydroalcoholic solvent comprising a lower alcohol and water in a weight ratio of about 60;
40 to about 85;
15;
wherein the lower alcohol is present in the hydroalcoholic foam in an amount of at least 60 wt-%;b) a polyethoxylated emulsifier; and c) an emollient, wherein the emollient is a dialkoxy dimethicone having the following chemical structure;
R—
O—
Si(CH3)2—
O[Si(CH3)2—
O]z—
Si(CH3)2—
ORwhere R is a straight chain alkyl group of 14-50, and z=5-300.
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Specification