Polycationic peptide hydrogel coatings for cardiovascular therapy

• US 7,803,394 B2
• Filed: 11/17/2006
• Issued: 09/28/2010
• Est. Priority Date: 06/21/2002
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Hossainy, Syed F. A.
• Primary Examiner(s): Azpuru; Carlos A
• Application Number:
  US11/601,388
• Publication Number:
  US 20070065478A1
• Time in Patent Office: 1,411 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2420/08 Coatings comprising two or more layers
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Coatings for implantable medical devices and methods for fabricating the same are disclosed. The coating includes a hydrogel including polycationic peptides, for example the R7.

Claims

1. A coating for an implantable medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a polycationic peptide and a second region free from the polycationic peptide;

wherein the hydrogel further comprises at least one substance selected from the group consisting of polyalginate, sulfonated dextran, poly(dimethylaminoethyl methacrylate), and poly(acrylic acid); and

wherein the peptide comprises a polyarginine having between about 5 and 1,000 repeating units.

2. The coating of claim 1, wherein the coating is on an implantable medical device, and the implantable medical device is a stent.

4. The coating of claim 1, wherein the at least one substance is poly(dimethyl-aminoethyl methacrylate), poly(acrylic acid), or polyalginate.

6. The coating of claim 1, wherein the region free from the polycationic peptide is positioned on the surface of the device and beneath the region including the polycationic peptide.

12. The coating of claim 1, wherein the first region further comprises another polymer different from the polycationic peptide and the at least one substance.

3. A coating for an implantable medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a polycationic peptide and at least one substance selected from the group consisting of polyalginate, sulfonated dextran, poly(dimethylaminoethyl methacrylate), and poly(acrylic acid), and a second region free from the polycationic peptide;

wherein the polycationic peptide comprises poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ

-guanidino-α

-aminobutyric acid), or a mixture of poly(L-arginine) and poly(D-arginine), and

wherein the poly(L-arginine), poly(D-arginine), poly(D,L-arginine), and the mixture of poly(L-arginine) and poly(D-arginine) independently have between about 5 and 1,000 repeating units.

5. The coating of claim 3, wherein the at least one substance is poly(dimethylaminoethyl methacrylate), poly(acrylic acid), or polyalginate.

10. The coating of claim 3, wherein the coating is on an implantable medical device and the device is a stent.

11. The coating of claim 3, wherein the region free from the polycationic peptide is positioned on the surface of the device and beneath the region including the polycationic peptide.

13. The coating of claim 3, wherein the first region further comprises another polymer different from the polycationic peptide and the at least one substance.

7. A coating for a medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a peptide and a second region free from the peptide;

wherein the peptide comprises a polyarginine having between about 5 and 1,000 repeating units; and

wherein the hydrogel is fabricated from poly(glutamic acid) and the peptide comprising the polyarginine, and the ratio of the peptide comprising the polyarginine to poly(glutamic acid) is from about 1;

1 to 5;

1.

8. The coating of claim 7, wherein the coating is on a medical device, and the device is a stent.

9. The coating of claim 7, wherein the region including the peptide is over the region free from the peptide.

14. The coating of claim 7, wherein the first region further comprises another polymer different from the polycationic peptide and the at least one substance.