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Polycationic peptide hydrogel coatings for cardiovascular therapy

  • US 7,803,394 B2
  • Filed: 11/17/2006
  • Issued: 09/28/2010
  • Est. Priority Date: 06/21/2002
  • Status: Expired due to Fees
First Claim
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1. A coating for an implantable medical device, the coating comprising two regions, a first region comprising a hydrogel comprising a polycationic peptide and a second region free from the polycationic peptide;

  • wherein the hydrogel further comprises at least one substance selected from the group consisting of polyalginate, sulfonated dextran, poly(dimethylaminoethyl methacrylate), and poly(acrylic acid); and

    wherein the peptide comprises a polyarginine having between about 5 and 1,000 repeating units.

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