Polycationic peptide coatings and methods of coating implantable medical devices
First Claim
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1. A method of coating an implantable medical device comprising:
- (a) incorporating a polycationic peptide into polymeric microspheres or beads;
(b) adding the microspheres or beads to a composition comprising a polymer; and
(c) applying the composition to a medical device,wherein the microspheres or beads are obtained by suspension polymerization of monomers.
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Abstract
Methods of forming coatings comprising a polycationic peptide for medical devices are disclosed. Also disclosed is a coating comprising a polycationic peptide.
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Citations
19 Claims
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1. A method of coating an implantable medical device comprising:
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(a) incorporating a polycationic peptide into polymeric microspheres or beads; (b) adding the microspheres or beads to a composition comprising a polymer; and (c) applying the composition to a medical device, wherein the microspheres or beads are obtained by suspension polymerization of monomers. - View Dependent Claims (2, 3, 8, 10, 11)
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4. A method of coating an implantable medical device comprising:
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(a) incorporating a polycationic peptide into polymeric microspheres or beads; (b) adding the microspheres or beads to a composition comprising a polymer; and (c) applying the composition to a medical device, wherein the microspheres or beads are obtained by emulsion copolymerization of at least one neutral monomer, at least one anionic monomer, at least one cross-linking monomer, or a combination thereof. - View Dependent Claims (5, 6, 7, 17, 18)
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9. A method of coating an implantable medical device comprising:
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(a) incorporating a polycationic peptide into polymeric microspheres or beads; (b) adding the microspheres or beads to a composition comprising a polymer; and (c) applying the composition to a medical device, wherein the polycationic peptide comprises heptaarginine. - View Dependent Claims (19)
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- 12. A coating for an implantable medical device, wherein the coating is UV-curable and comprises a hydrogel polymer and a polycationic peptide incorporated into the hydrogel polymer, wherein the polycationic peptide comprises heptaarginine.
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