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Methods for identification of eicosapentaenoic acid analogs using anti-inflammatory receptors

  • US 7,803,557 B2
  • Filed: 03/10/2008
  • Issued: 09/28/2010
  • Est. Priority Date: 03/05/2003
  • Status: Active Grant
First Claim
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1. A method for screening a candidate substance for anti-inflammatory activity, comprising:

  • contacting a cell that expresses a Reso E receptor with the candidate substance, wherein the Reso E receptor is a murine Reso E receptor according to SEQ. ID NO;

    2, a rat Reso E receptor according to SEQ. ID NO;

    3 or human Reso ER1 according to SEQ. ID NO;

    1;

    anddetecting a biological activity mediated by the Reso E receptor wherein contacting the cell comprises administering the candidate substance to an animal in vivo, and the biological activity is reduced expression of IL-12 and reduced migration of dendritic cells into T-cell areas of a spleen relative to an animal not administered the candidate substance.

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