Matrix optimization method of individually adapting therapy in an implantable cardiac therapy device

• US 7,805,194 B1
• Filed: 11/03/2006
• Issued: 09/28/2010
• Est. Priority Date: 11/03/2006
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Schecter, Stuart O.
• Primary Examiner(s): Manuel; George
• Assistant Examiner(s): Wieland; Robert N
• Application Number:
  US11/556,552
• Time in Patent Office: 1,425 Days
• Field of Search: 607 17- 19, 607/2, 607/6, 607/9, 607/14, 607/20, 607 23- 25, 600/510, 600/437, 604/27, 702/19
• US Class Current: 607/17
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber

Abstract

A system and method of adjusting therapy delivery in an implantable cardiac stimulation device including establishing a plurality of setting combinations for at least two variable parameters of the implantable cardiac stimulation device affecting delivery of therapy. At least one aspect of a patient'"'"'s physiologic performance is evaluated under individual ones of the plurality of setting combinations selected such that at least one of the two variable parameters vary among the plurality of combinations. A setting combination providing more optimal patient physiologic performance is programmed for future delivery of therapy. An external device can provide measurements indicative of cardiac performance. Measurements of cardiac performance can also be obtained by an implantable device.

Claims

1. A method of adjusting therapy delivery in an implantable cardiac stimulation device, the method comprising:

establishing a plurality of setting combinations for at least two variable parameters of the performance of the implantable cardiac stimulation device affecting delivery of therapy;

evaluating at least one aspect of a patient'"'"'s physiologic performance according to one or more measures under individual ones of the plurality of setting combinations wherein the plurality of setting combinations are selected such that at least one of the two variable parameters vary among the plurality of combinations;

evaluating how changing one of the performance parameters affects how a second performance parameter affects the patient'"'"'s physiologic performance according to the one or more measures;

selecting a setting combination providing more optimal patient physiologic performance; and

iterating the method with the plurality of setting combinations for the at least two variable parameters at a first graduation between settings of the variable parameters to determine a first more optimal setting combination; and

reiterating the method with the plurality of setting combinations at a second graduation between settings of the variable parameters to determine a second more optimal setting combination.

2. The method of claim 1, wherein establishing a setting combination comprises setting a timing interval as one or more of the at least two variables affecting therapy delivery.

3. The method of claim 2, wherein setting the timing interval comprises setting an atrioventricular interval (AVI).

4. The method of claim 1, wherein evaluating the patient'"'"'s physiologic performance comprises imaging the patient with an external imaging system.

5. The method of claim 4, wherein the evaluating further comprises determining an ejection fraction (EF) based on imaging data from the external imaging system.

6. The method of claim 1, wherein evaluating the patient'"'"'s physiologic performance comprises evaluating internally sensed signals indicative of the patient'"'"'s cardiac performance.

7. The method of claim 6, wherein evaluating the internally sensed signals comprises evaluating intracardiac electrogram (IEGM) signals indicative of ventricular-ventricular synchrony.

8. The method of claim 1, wherein the evaluating comprises determining a correction factor index representative of ratio of time of peak activation of two dysynchronous regions of a heart and wherein the more optimal setting combination corresponds to a respective correction factor index closest approaching a value of one.

9. A method of adjusting therapy delivery in an implantable cardiac stimulation device, the method comprising:

establishing a plurality of setting combinations for at least two variable parameters of the performance of the implantable cardiac stimulation device affecting delivery of therapy;

evaluating at least one aspect of a patient'"'"'s physiologic performance according to one or more measures under individual ones of the plurality of setting combinations wherein the plurality of setting combinations are selected such that at least one of the two variable parameters vary among the plurality of combinations;

evaluating how changing one of the performance parameters affects how a second performance parameter affects the patient'"'"'s physiologic performance according to the one or more measures;

selecting a setting combination providing more optimal patient physiologic performance;

iterating the method at a first patient metabolic rate to determine a first more optimal setting combination;

inducing at least a second metabolic rate of the patient;

reiterating the method at least the second metabolic rate; and

determining at least a second more optimal setting combination at the second metabolic rate.