Blood separation and concentration system
First Claim
Patent Images
1. An apparatus to produce concentrated blood components, which apparatus comprises:
- a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density, wherein the separation disc is rotatably mounted to a centrifuge chamber that comprises an iris door;
b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and
c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components.
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Abstract
This invention provides an apparatus and methods to consistently separate and concentrate selected blood components. The system includes, e.g., a computerized fluid handling system to transfer blood components between a centrifugal blood separation disc, containers and a concentrator.
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Citations
48 Claims
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1. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density, wherein the separation disc is rotatably mounted to a centrifuge chamber that comprises an iris door; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density, wherein the separation disc comprises welded ribs; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components.
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33. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density, wherein the separation disc comprises an inlet port and an outlet port, which ports are oriented in the same direction and wherein the separation disc comprises a keyway which controls the direction of the inlet port and outlet port; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components.
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34. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump, wherein the first pump comprises a turn counter operably connected to the control system, which control system thereby monitors one or more transfer volumes; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components.
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35. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components, wherein; an air detector is operably coupled to the first conduit, which air detector is operably connected to the control system; the first pump comprises a turn counter operably connected to the control system, whereby the control system determines a blood volume transferred (Vb) to the separation disc when the air is detected; and
,the control system compares an expected blood volume (Veb) entered by an operator to the blood volume (Vb) transferred, which computer directs one or more error notices to the operator if the blood volume (Vb) transferred is not within about 30% of the expected blood volume (Veb). - View Dependent Claims (36, 37, 38, 39, 40)
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41. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components, wherein the permeate side of the membrane drains into a filtrate container, which filtrate container comprises optical array volume detection, which optical array is operably connected to the control system, thereby transmitting the volume of filtrate (Vf) in the filtrate container. - View Dependent Claims (42, 43, 44)
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45. An apparatus to produce concentrated blood components, which apparatus comprises:
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a) a separation disc which receives blood through a first conduit, which separation disc rotates to generate centripetal force, thereby separating the blood into two or more blood components according to density; b) a control system operably connected to a first pump operably coupled to the first conduit, wherein the control system controls transfer of blood and/or blood components to the separation disc by controlling the pump; and c) a concentrator which receives one or more of the blood components from the separation disc through a second conduit, which concentrator comprises at least one ultrafiltration membrane, which membrane comprises a retentate side and a permeate side wherein, during operation of the apparatus, the blood components being contacted to the retentate side of the membrane with a pressure gradient, thereby forcing one or more low molecular weight molecules through the membrane to a permeate side of the membrane and concentrating blood components, wherein a RBC detector is operably coupled to the second conduit, which RBC detector is operably connected to the control system, wherein the control system terminates operation of the first pump on the first conduit when RBCs are detected at the RBC detector; the control system is operably connected to a junction valve, which junction valve is operably coupled to the first conduit, on actuation of which junction valve transfer of blood components from the separation disc is directed to a RBC holding container; and the control system directs actuation of the junction valve and directs reverse flow of the first pump after the termination of operation, whereby a residual blood component is transferred from the separation disc to the RBC holding container. - View Dependent Claims (46, 47, 48)
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Specification