Anti-IL-23 antibodies, compositions, methods and uses
First Claim
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1. An isolated nucleic acid molecule encoding an IL-23p19 antibody capable of binding to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO:
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Abstract
An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
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Citations
12 Claims
- 1. An isolated nucleic acid molecule encoding an IL-23p19 antibody capable of binding to human IL-23p19 at one or more regions of human IL-23p19 consisting of the amino acid residues selected from the group consisting of residues 93-102, 93-110, and 127-137 of SEQ ID NO:
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8. An isolated nucleic acid molecule encoding an IL-23p19 antibody, comprising at least one light chain variable region and at least one heavy chain variable region, said light chain variable region nucleotide sequence comprising:
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(a) a complementarity determining region light chain 1 (CDRL1) nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
9;(b) a CDRL2 nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
10; and(c) a CDRL3 nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
11,and said heavy chain variable region nucleotide sequence comprising; (d) a complementarity determining region heavy chain 1 (CDRH1) nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
4;(e) a CDRH2 nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
5; and(f) a CDRH3 nucleotide sequence encoding the amino acid sequence of SEQ ID NO;
6. - View Dependent Claims (9, 10, 11, 12)
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Specification