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IL-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses

  • US 7,807,471 B2
  • Filed: 06/26/2007
  • Issued: 10/05/2010
  • Est. Priority Date: 09/24/2004
  • Status: Active Grant
First Claim
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1. A method of selecting an anti-IL-23 antibody, comprising panning an antibody library with a variant murine p40 subunit of IL-23 and recovering the antibody binding to the variant murine p40subunit of IL-23, wherein the variant murine p40 subunit of IL-23 comprises at least one replacement from the group consisting of:

  • (i) replacing residues 97 and 98 of the amino acid sequence of SEQ ID NO;

    2 with residues 97-101 of the amino acid sequence of SEQ ID NO;

    1, (ii) replacing residues 135-142 of the amino acid sequence of SEQ ID NO;

    2 with residues 138-145 of the amino acid sequence of SEQ ID NO;

    1, and (iii) replacing residues 247-274 of the amino acid sequence of SEQ ID NO;

    2 with residues 250-269 of the amino acid sequence of SEQ ID NO;

    1.

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