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Biobeneficial coating compositions and methods of making and using thereof

  • US 7,807,722 B2
  • Filed: 11/26/2003
  • Issued: 10/05/2010
  • Est. Priority Date: 11/26/2003
  • Status: Expired due to Fees
First Claim
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1. A method of coating an implantable device comprisinga. providing a first block copolymer, wherein the first block copolymer comprises a block having a glass transition temperature (Tg) below body temperature and a second block having a Tg or a melting temperature (Tm) above body temperature, wherein the second block comprises styrene monomers,b. conjugating a biobeneficial polymer to the styrene monomers of the first block polymer by acylation followed by reductive amination of the acyl carbonyl to form a conjugate of the first block polymer and the biobeneficial polymer,c. applying a composition onto the implantable device to form a coating, wherein the composition comprises the first block copolymer conjugated with the biobeneficial polymer.

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