Biobeneficial coating compositions and methods of making and using thereof

• US 7,807,722 B2
• Filed: 11/26/2003
• Issued: 10/05/2010
• Est. Priority Date: 11/26/2003
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Pacetti, Stephen D.
• Primary Examiner(s): HARTLEY, MICHAEL G
• Application Number:
  US10/723,043
• Publication Number:
  US 20050112172A1
• Time in Patent Office: 2,505 Days
• Field of Search: None
• US Class Current: 514/772.1
• CPC Class Codes: A61K 9/284 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C08L 53/02 of vinyl-aromatic monomers and conjugated dienes

Abstract

A biobeneficial coating composition for coating an implantable device, such as a drug eluting stent, and a method of coating the device with the composition, and an implantable device coated with the composition are provided.

Claims

1. A method of coating an implantable device comprising

a. providing a first block copolymer, wherein the first block copolymer comprises a block having a glass transition temperature (T_g) below body temperature and a second block having a T_g or a melting temperature (T_m) above body temperature, wherein the second block comprises styrene monomers,

b. conjugating a biobeneficial polymer to the styrene monomers of the first block polymer by acylation followed by reductive amination of the acyl carbonyl to form a conjugate of the first block polymer and the biobeneficial polymer,

c. applying a composition onto the implantable device to form a coating, wherein the composition comprises the first block copolymer conjugated with the biobeneficial polymer.

2. The method of claim 1 wherein the composition further comprises a bioactive agent.

3. The method of claim 1 wherein the implantable device is a stent.

4. The method of claim 1 wherein the biobeneficial polymer is an amine-terminated PEG.