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Transgenic bovine having reduced prion protein activity and uses thereof

  • US 7,807,863 B2
  • Filed: 09/05/2008
  • Issued: 10/05/2010
  • Est. Priority Date: 11/08/2002
  • Status: Expired due to Term
First Claim
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1. A bovine whose genome comprises a non-naturally occurring mutation in one or both alleles of an endogenous prion nucleic acid, wherein said mutation comprises an insertion of a STOP codon, and wherein said bovine exhibits reduced functional prion production.

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