Implantable medical device with chemical sensor and related methods
First Claim
1. An implantable medical device comprising:
- a cardiac rhythm management system comprisingan implantable pulse generator comprisinga power source,circuitry for delivering at least one of cardiac pacing and cardiac shock therapy; and
an implantable housing configured to encapsulate the circuitry for delivering at least one of cardiac pacing and cardiac shock therapy; and
a chronically implantable chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid, the chemical sensor comprising;
an optical sensing element selective for potassium ion comprising a polymeric matrix permeable to sodium ions, potassium ions, and hydronium ions;
an optical excitation assembly configured to illuminate the optical sensing element;
an optical detection assembly configured to receive light from the optical sensing element, andan opaque cover layer disposed over a side of the sensing element.
1 Assignment
0 Petitions
Accused Products
Abstract
In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
221 Citations
28 Claims
-
1. An implantable medical device comprising:
-
a cardiac rhythm management system comprising an implantable pulse generator comprising a power source, circuitry for delivering at least one of cardiac pacing and cardiac shock therapy; and an implantable housing configured to encapsulate the circuitry for delivering at least one of cardiac pacing and cardiac shock therapy; and a chronically implantable chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid, the chemical sensor comprising; an optical sensing element selective for potassium ion comprising a polymeric matrix permeable to sodium ions, potassium ions, and hydronium ions; an optical excitation assembly configured to illuminate the optical sensing element; an optical detection assembly configured to receive light from the optical sensing element, and an opaque cover layer disposed over a side of the sensing element. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
-
-
28. An implantable cardiac rhythm management system comprising:
-
a pulse generator comprising circuitry for delivering at least one of cardiac pacing and cardiac shock therapy; and a chronically implantable optical chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an analyte concentration in a bodily fluid, the chemical sensor comprising; an optical sensing element specific for potassium ion comprising a plurality of beads; an optical excitation assembly configured to illuminate the optical sensing element; and an optical detection assembly configured to receive light from the optical sensing element.
-
Specification