Memantine titration/compliance dosage methods

• US 7,810,643 B2
• Filed: 07/07/2006
• Issued: 10/12/2010
• Est. Priority Date: 07/16/2003
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Le Espiritu, J. Abraham M., Terwilliger, Rodney J., Vander Zanden, John Jacob, Kurjan, Richard, Firestone, Bruce A., Kuan, Teresa, Chang, Chin-Ming, Cheetham, Janet K.
• Primary Examiner(s): Gehman; Bryon P
• Application Number:
  US11/483,039
• Publication Number:
  US 20060278557A1
• Time in Patent Office: 1,558 Days
• Field of Search: 206/528, 206531-532, 206534-5342, 206538-539, 424/400, 514/662
• US Class Current: 206/534
• CPC Class Codes: A61J 1/035 Blister-type containers blisters in general B65D75/36
• CPC Class Codes: A61J 7/04 Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics

Abstract

A titration package and method for enabling compliance with a regimen of changing dosage of medication over a period of time includes a backing having an array of receivers with the array including a plurality of columns and a plurality of rows. A plurality of sets of Memantine tablets are provided with each tablet set having a common dose of medication and a different does than a tablet of a different set. Each set of tablets is disposed in receivers of one having an adjacent row and an adjacent column. Indicia is provided and disposed adjacent to the columns and rows for displaying common days and successive weeks.

Claims

1. A method for enabling compliance with a regimen of changing dosage of medication, the method comprises the steps of:

providing a backing having an array of receivers, said array including a plurality of columns and a plurality of rows;

disposing a plurality of sets of tablets in the receivers, each tablet in a set having a common dose of medication and a different dose than a tablet of a different set, each set being disposed in receivers of one of an adjacent row and an adjacent column;

different sets of tablets are disposed in different rows, each row being indicated as a successive week, each column being indicated as a different day of the week, sets of tablets having increased doses being disposed in receivers of rows indicated as successive weeks; and

providing indicia adjacent the columns and rows indicating common days and successive weeks.

2. A method of treating a human patient to reduce damage to retinal ganglion cells associated with glaucoma, said method comprising providing a titration package for enabling compliance with a regimen of changing dosage of medication over a period of time, the package comprising:

a backing having an array of receivers, said array including a plurality of columns and a plurality of rows;

a plurality of sets of tablets, each tablet in a set having a common dose of the medication and a different dose than a tablet of a different set, each set being disposed in receivers of one of an adjacent row and an adjacent column;

different sets of tablets are disposed in different rows, each row being indicated as a successive week, each column being indicated as a different day of the week, sets of tablets having increased doses being disposed in receivers of rows indicated as successive weeks; and

indicia disposed adjacent the columns and rows for displaying common days and successive weeks.

3. The method according to claim 2 wherein the medication comprises Memantine.

4. The method according to claim 2 wherein the sets of tablets have 5 mg, 10 mg, 15 mg, and 20 mg doses of Memantine.

5. The method according to claim 2 wherein different sets of tablets are disposed in different columns, each column being indicated as a successive week, each row being indicated as a different day of the week.

6. The method according to claim 5 wherein sets of tablets have increased doses are disposed in receivers of columns indicated as successive weeks.