Biosensors and methods of making
First Claim
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1. A biosensor comprising:
- (a) a first and a second substrate;
(b) a sample chamber positioned between the first substrate and the second substrate;
(c) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, positioned within a portion of the sample chamber, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and
(d) wherein the biosensor comprises a proximal end, a distal end that engages with a meter, a first side extending between the proximal end and the distal end of the sensor, and a second side extending between the proximal end and the distal end of the sensor, and wherein the incompressible element extends from an edge of the first side to an edge of the second side of the biosensor.
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Abstract
Devices and methods for determining the concentration of an analyte in a sample of liquid are provided.
48 Citations
27 Claims
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1. A biosensor comprising:
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(a) a first and a second substrate; (b) a sample chamber positioned between the first substrate and the second substrate; (c) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, positioned within a portion of the sample chamber, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and (d) wherein the biosensor comprises a proximal end, a distal end that engages with a meter, a first side extending between the proximal end and the distal end of the sensor, and a second side extending between the proximal end and the distal end of the sensor, and wherein the incompressible element extends from an edge of the first side to an edge of the second side of the biosensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A biosensor strip for determining the concentration of an analyte in a sample, the biosensor strip having a first side and a second side comprising:
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(a) a first substrate; (b) a second substrate in covering relation to the first substrate; (c) a sample chamber present between the first substrate and the second substrates; (d) an electrode arrangement present between the first substrate and the second substrate and in the sample chamber; (e) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, extending between an edge of the first side and an edge of the second side of the sensor in the sample chamber which forms an opening between the first substrate and the second substrate at one of the first side edge and the second side edge, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and (f) sensing chemistry proximate the incompressible element. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of manufacturing a sensor, the method comprising:
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(a) positioning an incompressible element on a first substrate, wherein the incompressible element is a monofilament, a thread or a yarn; (b) overlying a second substrate over the first substrate and incompressible element to form a layered construction having at least one sample chamber, wherein the incompressible element is positioned within a portion of the sample chamber and defines the structure of the sample chamber in the absence of a spacer layer, and wherein the second substrate is deformable and deforms due to the incompressible element; and (c) converting the layered construction into at least one sensor, each of the at least one sensor having a sample chamber. - View Dependent Claims (25, 26, 27)
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Specification