Biosensors and methods of making
First Claim
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1. A sensor for use in determining a concentration of a ketone body in a sample, comprising:
- (a) a first and a second substrate;
(b) a sample chamber comprising ketone sensing chemistry positioned between the first substrate and the second substrate;
(c) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, positioned within a portion of the sample chamber, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and
(d) wherein the sensor comprises a proximal end, a distal end that engages with a meter, a first side extending between the proximal end and the distal end of the sensor, and a second side extending between the proximal end and the distal end of the sensor, and wherein the incompressible element extends from an edge of the first side to an edge of the second side of the sensor.
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Abstract
Devices and methods for determining the concentration of an analyte in a sample of liquid are provided.
45 Citations
23 Claims
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1. A sensor for use in determining a concentration of a ketone body in a sample, comprising:
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(a) a first and a second substrate; (b) a sample chamber comprising ketone sensing chemistry positioned between the first substrate and the second substrate; (c) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, positioned within a portion of the sample chamber, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and (d) wherein the sensor comprises a proximal end, a distal end that engages with a meter, a first side extending between the proximal end and the distal end of the sensor, and a second side extending between the proximal end and the distal end of the sensor, and wherein the incompressible element extends from an edge of the first side to an edge of the second side of the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A sensor for use in determining a concentration of a ketone body in a sample, the sensor having a first side and a second side comprising:
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(a) a first substrate; (b) a second substrate in covering relation to the first substrate; (c) a sample chamber present between the first substrate and the second substrates; (d) an electrode arrangement present between the first substrate and the second substrate and in the sample chamber; (e) an incompressible element, wherein the incompressible element is a monofilament, a thread or a yarn, extending between an edge of the first side and an edge of the second side of the sensor in the sample chamber which forms an opening between the first substrate and the second substrate at one of the first side edge and the second side edge, wherein the incompressible element defines the structure of the sample chamber in the absence of a spacer layer, and wherein the first substrate is deformable and deforms due to the incompressible element; and (f) ketone sensing chemistry proximate the incompressible element. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification