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GITR-binding antibodies

  • US 7,812,135 B2
  • Filed: 03/27/2006
  • Issued: 10/12/2010
  • Est. Priority Date: 03/25/2005
  • Status: Active Grant
First Claim
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1. An isolated monoclonal antibody comprising a light chain and a heavy chain, or an antigen-binding fragment thereof, which antibody or antigen-binding fragment specifically binds glucocorticoid-induced TNFR family-related receptor (GITR), wherein said antibody or antigen-binding fragment thereof comprises (a) the heavy chain variable region set forth in amino acid residues 20-138 of SEQ ID NO:

  • 1 or amino acid residues 20-138 of SEQ ID NO;

    66 and (b) the light chain variable region set forth in amino acid residues 21-127 of SEQ ID NO;

    2.

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