Implantable tissue ischemia sensor

• US 7,813,778 B2
• Filed: 07/29/2005
• Issued: 10/12/2010
• Est. Priority Date: 07/29/2005
• Status: Expired due to Fees

• Current Assignee: JB IP Acquisitions LLC
• Original Assignee: Spectros Corporation (AliphCom Corp.)
• Inventors: Fierro, Michael R., Benaron, David A., Parachikov, Ilian H.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US11/193,071
• Publication Number:
  US 20070027371A1
• Time in Patent Office: 1,901 Days
• Field of Search: None
• US Class Current: 600/323
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

An implantable ischemia detection system in which a white LED (105) produces a continuous, visible, broadband light illuminating a target site (125). Light backscattered by the target is collected by a sensor (155), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (167). Power is provided by an internal power source (179). The entire implantable device is encapsulated by a biocompatible shell (102) to add long-term safety with regard to implantation.

Claims

1. An implantable device comprising:

a light source for illuminating a target with light;

a sensor configured so as to detect light backscattered substantially from local capillary and extravascular tissue within the target site onto said sensor and to provide a tissue oxygenation output signal that is a direct function of the presence or degree of internal tissue ischemia based at least on said light backscattered from said site;

a power source configured to supply energy to said sensor, and said light source; and

an exterior shell enclosing said power source, light source, and sensor configured so as to be biocompatible with respect to implantation internally wherein said external shell is a swallowable capsule for passage through the gastrointestinal system.

2. The implantable device of claim 1, wherein said light source is a broadband white LED.

3. The implantable device of claim 1, wherein said sensor is a CCD configured so as to be wavelength sensitive.

4. The implantable device of claim 1, wherein said output signal is generated using differential spectroscopy.

5. The implantable device of claim 1, wherein said power source is an inductive coil for receiving power.

6. The implantable device of claim 1, wherein said measure of internal tissue ischemia is a function selected from the list of functions comprising impending risk of tissue death, impending risk of organ rejection, cardiac function, treatment efficacy for arterial or venous vascular disease, risk of renal damage, risk of brain injury, risk of colon death, risk of limb amputation, risk of ulcer healing, or risk of critical limb ischemia.

7. The device of claim 1, further comprising a sending unit for receiving the output signal and transmitting said output signal.

8. The implantable device of claim 7, wherein said output signal is a function of a measure selected from at least one of a list of measures comprising tissue capillary hemoglobin saturation, cellular myoglobin saturation, and intracellular mitochondrial cytochrome saturation.

9. The implantable device of claim 7, wherein said sending unit is comprised of any one or more of an RF transmitter, an RFID chip, or an optical fiber.

10. An implantable device comprising:

a light source for illuminating a target with light;

a sensor configured so as to detect light backscattered substantially from local capillary and extravascular tissue within the target site onto said sensor and to provide a tissue oxygenation output signal that is a direct function of the presence or degree of internal tissue ischemia based at least on said light backscattered from said site;

a power source configured to supply energy to said sensor, and said light source;

an exterior shell enclosing said power source, light source, and sensor configured so as to be biocompatible with respect to implantation internally; and

a sending unit for receiving the output signal and transmitting the output signal, wherein said sending unit is coupled to an implanted pacemaker, for the purpose of real time feedback.

11. The implantable device of claim 10, wherein said external shell is a fully-sealed biocompatible shell for implantation in an organ or tissue.

12. The implantable device of claim 10, wherein said measure of tissue ischemia is a function selected from the list of functions comprising impending risk of tissue death, impending risk of organ rejections, cardiac functions, treatment efficacy for arterial or venous vascular disease, risk of renal damage, risk of brain injury, risk of colon death, risk of limb amputation, risk of ulcer healing, or risk of critical limb ischemia.

13. The implantable device of claim 10, wherein said light source is a broadband white LED.

14. The implantable device of claim 10, wherein said sensor is a CCD configured so as to be wavelength sensitive.

15. The implantable device of claim 10, wherein said output signal is a function of a measure selected from at least one of a list of measures comprising tissue capillary hemoglobin saturation, cellular myoglobin saturation, and intracellular mitochondrial cytochrome saturation.

16. The implantable device of claim 10, wherein said output signal is generated using differential spectroscopy.

17. The implantable device of claim 10, wherein said power source is an inductive coil for receiving power.

18. The implantable device of claim 10, wherein said sending unit is comprised of any one or more of an RF transmitter, an RFID chip, or an optical fiber.