Biosensors and methods for making and using them
First Claim
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1. A membrane for use with an implantable analyte sensor comprising:
- a first layer comprising a biocompatible polymer composition that is;
impermeable to immunoglobulins; and
permeable to oxygen, glucose and lactate; and
a second layer coupled to the first layer, the second layer comprising a plurality of pores disposed therein and wherein at least one of the plurality of pores disposed in the second layer contains functionalized poly(dimethyl siloxane), functionalized poly(dimethyl siloxane) copolymer or a mixture of functionalized poly(dimethyl siloxane) and functionalized poly(dimethyl siloxane) copolymer of the second layer,wherein the membrane is more permeable to oxygen than glucose and/or lactate.
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Abstract
Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
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Citations
12 Claims
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1. A membrane for use with an implantable analyte sensor comprising:
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a first layer comprising a biocompatible polymer composition that is; impermeable to immunoglobulins; and permeable to oxygen, glucose and lactate; and a second layer coupled to the first layer, the second layer comprising a plurality of pores disposed therein and wherein at least one of the plurality of pores disposed in the second layer contains functionalized poly(dimethyl siloxane), functionalized poly(dimethyl siloxane) copolymer or a mixture of functionalized poly(dimethyl siloxane) and functionalized poly(dimethyl siloxane) copolymer of the second layer, wherein the membrane is more permeable to oxygen than glucose and/or lactate. - View Dependent Claims (2, 3, 4, 7)
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5. The membrane of 2, wherein the implantable analyte sensor is a glucose sensor that comprises a layer of glucose oxidase and further wherein the size of the pores is controlled to optimize the relative concentrations of glucose and oxygen that react with the glucose oxidase.
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6. The membrane of 2, wherein the implantable analyte sensor is a glucose sensor that comprises a layer of glucose oxidase and further wherein the geometry of the pores is controlled to optimize the relative concentrations of glucose and oxygen that react with the glucose oxidase.
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8. A membrane for use with an implantable analyte sensor comprising:
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a first layer comprising a biocompatible polymer composition that is; impermeable to immunoglobulins; and permeable to oxygen, glucose and lactate; and a second layer coupled to the first layer comprising functionalized poly(dimethyl siloxane), functionalized poly(dimethyl siloxane) copolymer or a mixture of functionalized poly(dimethyl siloxane) and functionalized poly(dimethyl siloxane) copolymer, wherein the membrane is more permeable to oxygen than glucose and/or lactate, and wherein the first or second layer comprises a plurality of pores disposed therein and further wherein at least one of the plurality of pores contains a biocompatible hydrophilic polymer that facilitates hydration of the implantable analyte sensor. - View Dependent Claims (9, 10, 11, 12)
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Specification