Regional therapies for treatment of pain

• US 7,813,803 B2
• Filed: 03/14/2006
• Issued: 10/12/2010
• Est. Priority Date: 06/09/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Singhal, Ruchika, Heruth, Kenneth T., Lent, Mark S., Schendel, Michael J., King, Gary W.
• Primary Examiner(s): Getzow; Scott M
• Assistant Examiner(s): PATTON, AMANDA K
• Application Number:
  US11/374,852
• Publication Number:
  US 20070021801A1
• Time in Patent Office: 1,673 Days
• Field of Search: 607/2, 607/46
• US Class Current: 607/46
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/025 Digital circuitry features of electrotherapy devices, e.g. memory, clocks, processors
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/37229 Shape or location of the implanted or external antenna

Abstract

Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The subcutaneous stimulation may be applied in proximity to a structure in the back, such as discs, facet joints, nerve roots or ganglions, sympathetic chain, ligaments, muscles, and the like. Subcutaneous stimulation at high and low frequencies applied in combination with epidural stimulation is also described.

Claims

1. A method for treating pain in a subject in need thereof, the method comprising:

generating via a pulse generator implanted in the subject a first electrical signal having a frequency of less than about 20 Hz and applying the first electrical signal to a first region of subcutaneous tissue in proximity to a source or pain of the subject via a first electrode implanted proximate to the first region to treat the pain; and

generating via the pulse generator a second electrical signal having a frequency of greater than about 50 Hz and applying the second electrical signal to a second region of subcutaneous tissue in proximity to the source of pain of the subject via a second electrode implanted proximate to the second region to treat the pain,

wherein the first and second regions are different, the second electrical signal is not applied via the first electrode, and the first electrical signal is not applied via the second electrode.

2. The method of claim 1, wherein applying the first electrical signal to the first region in proximity to the source of pain comprises applying the signal in proximity to a structure of the back of the patient.

3. The method of claim 2, wherein applying the signal in proximity to a structure of the back of the patient comprises applying the signal in proximity to a disc or facet joint.

4. The method of claim 1, wherein applying the second electrical signal to the second region in proximity to the source of pain comprises applying the signal in proximity to a structure of the back of the patient.

5. The method of claim 4, wherein applying the signal in proximity to a structure of the back of the patient comprises applying the signal in proximity to a disc or facet joint.

6. The method of claim 1, wherein applying the first electrical signal to the first region in proximity to the source of pain comprises applying the signal in proximity to a muscle, nerve or ligament.

7. The method of claim 1, wherein applying the second electrical signal to the second region in proximity to the source of pain comprises applying the signal in proximity to a muscle, nerve or ligament.

8. The method of claim 1, wherein applying the first electrical signal and applying the second electrical signal comprises alternating between application of the first signal and application of the second signal.

9. The method of claim 8, wherein alternating between application of the first signal and application of the second signal comprises application of the first signal for between about one second and about eight hours and application of the second signal for between about one second and about eight hours.

10. A method for treating pain in a subject in need thereof, the method comprising:

generating via a pulse generator implanted in the subject a first electrical signal having a frequency of less than about 20 Hz and applying the first electrical signal to a first region of subcutaneous tissue via at least one electrode of a set of one or more electrodes implanted in the subject in proximity to a source of pain to treat pain; and

generating via the implantable pulse generator a second electrical signal having a frequency of greater than about 50 Hz and applying the second electrical signal to a second region of subcutaneous tissue via at least one electrode of the set of the one or more electrodes to treat pain,

wherein the applying the first signal and applying the second signal comprises applying at least one of the first and second signals to at least one different electrode than the at least one electrode to which the other of the first and second signals is applied.

11. The method of claim 10, wherein the set of one or more electrodes comprises one or more electrodes on one or more subcutaneously implanted leads.

12. The method of claim 10, wherein at least one of the set of one or more electrodes is implanted in proximity to a nerve, muscle, or ligament.

13. The method of claim 10, wherein at least one of the set of one or more electrodes is implanted in proximity to a structure of the subject'"'"'s back.

14. The method of claim 13, wherein the at least one electrode is implanted in proximity to a disc or facet joint.

15. The method of claim 11, wherein the one or more subcutaneously implanted leads comprise one or more leads subcutaneously implanted parallel to the spinal column.

16. The method of claim 15, wherein at least a plurality of electrodes on at least one of the one or more leads extend over more than one vertebral level.

17. The method of claim 10, wherein the set of one or more electrodes is placed subcutaneously along the subject'"'"'s spinal column such that the set of one or more electrodes extend over more than one vertebral level.

18. A method for treating pain in a subject in need thereof, the method comprising:

generating via a pulse generator implanted in the subject a first electrical signal having a frequency of less than about 20 Hz and applying the first electrical signal to a first region of subcutaneous tissue via at least one electrode of a first set of one or more electrodes implanted in the subject in proximity to a first source of pain to treat pain; and

generating via the pulse generator a second electrical signal having a frequency of greater than about 50 Hz and applying the second electrical signal to a second region of subcutaneous tissue via at least one electrode of a second set of one or more electrodes implanted in the subject in proximity to a second source of pain, which is the same or different than the first source of pain, to treat pain, wherein the first and second regions are different the second electrical signal is not applied by the at least one electrode of the first set of one or more electrodes, and the first electrical signal is not applied by the at least one electrode of the second set of one or more electrodes.

19. The method of claim 18, wherein the first set of electrodes comprises electrodes on a first set of one or more implanted leads and wherein the second set of electrodes comprises electrodes on a second set of one or more implanted leads.

20. The method of claim 18, wherein at least one of the first set of one or more electrodes is implanted in proximity to a structure of the back of the subject and wherein at least one of the second set of one or more electrodes is implanted in proximity to a structure of the back of the subject.

21. The method of claim 18, wherein the first and second set of electrodes are implanted in proximity to the same source of pain.

22. A method for treating pain in a subject in need thereof, the method comprising:

applying a first electrical signal to at least one electrode of a first set of one or more electrodes implanted in the subject in proximity to a source of pain to treat pain, the first electrical signal comprising a frequency of less than about 20 Hz; and

applying a second electrical signal to at least one electrode of a second set of one or more electrodes epidurally implanted in the subject to treat pain, the second electrical signal comprising a frequency of greater than about 50 Hz,

wherein the second electrical signal is not applied by the at least one electrode of the first set of one or more electrodes and the first electrical signal is not applied by the at least one electrode of the second set of one or more electrodes.

23. The method of claim 22, wherein at least one of the first set of one or more electrodes is implanted in proximity to a structure of the back of the subject.

24. The method of claim 22, further comprising applying a third electrical signal to at least one electrode of the first set of one or more electrodes, the third electrical signal comprising a frequency of greater than about 50 Hz.

25. The method of claim 24, wherein applying the first electrical signal and applying the third electrical signal comprises varying between applying the first signal and applying the third signal.

26. The method of claim 25, wherein varying between applying the first signal and applying the third signal comprises applying the first signal for between about one second and eight hours and applying the third signal between about one second and about eight hours.

27. The method of claim 25, wherein applying the first and third electrical signals comprises applying the signals to a disc or a facet joint.

28. The method of claim 22, wherein applying the first electrical signal to the first subcutaneous region comprises applying the signal to a disc or facet joint.

29. A computer readable medium programmed with instructions to cause an implantable pulse generator to alternate in a periodic manner between generating a first electrical signal having a frequency between about 50 Hz and about 75 Hz for application to a first electrode but not a second electrode and generating a second electrical signal having a frequency between about 10 Hz and about 20 Hz for application to the second electrode but not the first electrode.

30. The computer readable media of claim 29, wherein the instructions cause the implantable pulse generator to generate a repeating pattern of the first signal for between about one second and eight hours and the second signal for between about one second and about eight hours.

31. The computer readable medium of claim 30, wherein the instructions cause the pulse generator to generate a repeating pattern of the first signal for between about two minutes and about two hours and the second signal for between about two minutes and about two hours.

32. An implantable pulse generator comprising the computer readable media of claim 29.

33. An implantable pulse generator comprising the computer readable media of claim 30.

34. A programming device capable of communicating instructions to an implantable pulse generator comprising the computer readable media of claim 29.

35. A programming device capable of communicating instructions to an implantable pulse generator comprising the computer readable media of claim 30.