Subcardiac threshold vagal nerve stimulation

• US 7,813,805 B1
• Filed: 01/11/2006
• Issued: 10/12/2010
• Est. Priority Date: 01/11/2006
• Status: Expired due to Fees

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Farazi, Taraneh Ghaffari
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Behringer; Luther G
• Application Number:
  US11/330,885
• Time in Patent Office: 1,735 Days
• Field of Search: 607/5, 607/6, 607/9, 607/45, 607/2, 607/28, 607/39, 607/118, 607/27, 607/72, 607/76
• US Class Current: 607/50
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/3688 configured for switching the pacing mode, e.g. from AAI to DDD

Abstract

In one embodiment, an implantable stimulation apparatus includes a vagal nerve stimulator configured to generate electrical pulses below a cardiac threshold of a heart, and an electrode coupled to the vagal nerve stimulator which is configured to transmit the electrical pulses below the cardiac threshold, to a vagal nerve so as to inhibit injury resulting from an ischemia and/or reduce injury resulting from an ischemia. In another embodiment, an implantable stimulation apparatus includes a vagal nerve stimulator configured to generate electrical pulses below a cardiac threshold, and includes an electrode, which is coupled to the vagal nerve stimulator and configured transmit electrical pulses to a vagal nerve so as to reduce a defibrillation threshold of the heart.

Claims

1. An implantable stimulation apparatus comprising:

a) a vagal nerve stimulator configured to generate electrical pulses having an energy insufficient to slow a patient'"'"'s heart rate;

b) a first electrode coupled to the vagal nerve stimulator and configured to transmit the electrical pulses to a vagal nerve so as to at least one of;

(1) inhibit injury resulting from an ischemia;

or (2) reduce injury resulting from an ischemia;

c) a second electrode configured to sense cardiac activity of a patient'"'"'s heart; and

d) a control circuit coupled to the second electrode and the vagal nerve stimulator, the control circuit configured to;

use the cardiac activity to determine an energy of the electrical pulses at which the patient'"'"'s heart rate is not slowed;

determine an energy of the electrical pulses at which the patient'"'"'s heart rate is slowed by increasing the enemy of the electrical pulses until the sensed cardiac activity indicates a slowing of the heart rate; and

adjust energy parameters of the electrical pulses so that the energy of the electric pulses is insufficient to slow the patient'"'"'s heart rate.

2. The implantable stimulation apparatus of claim 1, wherein the control circuit is further configured to detect the ischemia.

3. The implantable stimulation apparatus of claim 1, wherein the control circuit is further configured to detect a heart arrhythmia based on the cardiac activity, the implantable stimulation device further comprising:

a) a third electrode configured to transmit stimulation pulses to the heart; and

b) a heart stimulator coupled to the third electrode and configured to generate the stimulation pulses for treating the heart arrhythmia.

4. The implantable stimulation apparatus of claim 1, wherein the first electrode comprises at least one of:

(a) a flexible flap for wrapping around the vagal nerve;

or (b) a helix shape for wrapping around the vagal nerve.

5. The implantable stimulation apparatus of claim 1, wherein the vagal nerve stimulator is configured to supply electrical pulses comprising:

(a) a frequency in a range of about 10 Hertz to about 100 Hertz;

(b) a pulse width in a range of about 100 microseconds to about 5 milliseconds;

(c) a voltage amplitude in a range of 0.5 volts to 20 volts; and

(d) a current below 20 milliamps.

6. The implantable stimulation apparatus of claim 5, wherein the vagal nerve stimulator is configured to supply electrical pulses comprising a current below 1 milliamp.

7. The implantable stimulation apparatus of claim 1, wherein the vagal nerve stimulator is configured so as to be capable of supplying electrical pulses comprising at least one of:

(a) continuous pulses;

(b) periodic pulses;

or (c) event triggered pulses.

8. An implantable stimulation apparatus comprising:

a) a first electrode configured to sense cardiac activity of a heart;

b) a vagal nerve stimulator configured to generate electrical pulses having an energy sufficient to treat ischemia without slowing of the heart rate;

c) a second electrode coupled to the vagal nerve stimulator and configured to transmit the electrical pulses to a vagal nerve for treating an ischemia; and

d) a controller coupled to the first electrode and the vagal nerve stimulator, the controller being configured to control the vagal nerve stimulator based on the cardiac activity, wherein the controller is configured to reduce the energy of the electrical pulses if the sensed cardiac activity indicates a reduction of the beat rate of the heart, and wherein the controller is configured to increase the energy of the electrical pulses until the sensed cardiac activity indicates a slowing of the beat rate of the heart.

9. The implantable stimulation apparatus of claim 8, wherein the controller is further configured to detect the ischemia based on the cardiac activity.

10. The implantable stimulation apparatus of claim 8, wherein the controller is further configured to detect a heart arrhythmia based on the cardiac activity, the implantable stimulation device further comprising:

a) a third electrode configured to transmit stimulation pulses to the heart; and

b) a heart stimulator coupled to the third electrode and configured to generate the stimulation pulses for treating the heart arrhythmia.

11. The implantable stimulation apparatus of claim 8, wherein the vagal nerve stimulator is configured so as to be capable of supplying electrical pulses comprising at least one of:

(a) continuous pulses;

(b) periodic pulses;

or (c) event triggered pulses.

12. A method comprising:

determining an energy of electrical pulses sufficient to treat ischemia in a patient without slowing of the patient'"'"'s heart rate when delivered to a vagal nerve;

determining an energy of the electrical pulses at which the patient'"'"'s heart rate is slowed when delivered to the vagal nerve by increasing the energy of the electrical pulses until the sensed cardiac activity indicates a slowing of the heart rate;

generating electrical pulses having said energy sufficient to treat ischemia in a patient without slowing of the patient'"'"'s heart rate; and

treating an ischemia by transmitting the electrical pulses to the vagal nerve.

13. The method of claim 12, wherein treating the ischemia comprises transmitting the electrical pulses to the vagal nerve to reduce injury resulting from the ischemia.

14. The method of claim 12, wherein treating the ischemia comprises transmitting the electrical pulses to the vagal nerve to inhibit injury resulting from the ischemia.

15. The method of claim 12 further comprising:

sensing cardiac activity of the heart, wherein the energy of the electrical pulses is determined based on the cardiac activity.

16. The method of claim 15 further comprising detecting the ischemia based on the cardiac activity.

17. The method of claim 15 further comprising:

detecting a heart arrhythmia based on the cardiac activity;

generating stimulation pulses for treating the heart arrhythmia; and

transmitting the stimulation pulses to the heart.

18. The method of claim 12, wherein the electrical pulses have:

(a) a frequency in a range of 10 Hertz to 100 Hertz (b) a pulse width in a range of 100 microseconds to 5 milliseconds;

(c) a voltage amplitude in a range of 0.5 volts to 20 volts; and

(d) a current below 20 milliamps.

19. The method of claim 18, wherein the electrical pulses have a current below 1 milliamp.

20. The method of claim 12, wherein the electrical pulses are periodic electrical pulses.

21. A method comprising:

sensing cardiac activity of a heart;

detecting an ischemia based on the cardiac activity;

determining an energy of electrical pulses effective to treat ischemia in a patient when delivered to a vagal nerve without slowing of the patient'"'"'s heart rate based on the cardiac activity of the patient;

determining an energy of the electrical pulses at which the patient'"'"'s heart rate is slowed when delivered to the vagal nerve by increasing the energy of the electrical pulses until the sensed cardiac activity indicates a slowing of the heart rate;

generating electrical pulses having said energy sufficient to treat ischemia in a patient without slowing of the patient'"'"'s heart rate; and

transmitting the electrical pulses having said energy sufficient to treat ischemia in a patient without slowing of the patient'"'"'s heart rate to the vagal nerve for treating an ischemia.

22. The method of claim 21 further comprising controlling the energy of the electrical pulses based on the cardiac activity.

23. The method of claim 21 further comprising:

detecting a heart arrhythmia based on the cardiac activity;

generating stimulation pulses for treating the heart arrhythmia; and

transmitting the stimulation pulses to the heart.

24. The method of claim 21, wherein the electrical pulses are event triggered pulses.