Apparatus and method for providing optimal concentrations for medication infusions

• US 7,813,880 B2
• Filed: 02/25/2005
• Issued: 10/12/2010
• Est. Priority Date: 03/25/2004
• Status: Active Grant

• Current Assignee: University of Maryland Baltimore County (University of Maryland)
• Original Assignee: University of Maryland Baltimore County (University of Maryland)
• Inventors: Hilmas, Elora, Vaidya, Vinay, Mathews, LeAnthony, Gaffoor, Mohamed
• Primary Examiner(s): Zhou; Shubo (Joe)
• Application Number:
  US11/065,026
• Publication Number:
  US 20050216203A1
• Time in Patent Office: 2,055 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

Optimum concentrations for a drug administered as a medical infusion to a patient, particularly a pediatric patient, are determined. The determination is made using inputs regarding (1) the drug to be administered; (2) the patient; and (3) the infusion process. The optimum concentrations are displayed to a user, such as any health care provider. A chart illustrating the distributions of concentrations over a range of doses and patient weights is also provided.

Claims

1. A method for determining supply concentrations of a drug to administer to a patient as a continuous infusion, comprising:

receiving drug data that indicates an entire dose range between a minimum effective dose for a drug and a maximum allowable dose for the drug;

receiving patient data that indicates a range of patient weights of patients to be treated with the drug;

receiving pump data that indicates a minimum infusion rate of an infusion pump; and

determining by a microprocessor, based on the drug data, the patient data and the pump data, a limited set of concentrations for drug supply that is used in continuous infusions for the entire range of patient weights across the entire dose range between the minimum effective dose for the drug and the maximum allowable dose for the drug,

wherein the limited set of concentrations contains two to four optimal concentrations.

2. The method as recited in claim 1, wherein:

receiving the patient data further comprises receiving patient data that indicates a maximum fluid load to be received by a patient during administration of the drug; and

determining the limited set of concentrations further comprises determining the limited set of concentration based at least in part on the maximum fluid load.

3. The method as recited in claim 1, wherein:

receiving the drug data further comprises receiving drug data that indicates at least one of a maximum permissible concentration for drug supply or a commercial premix concentration for drug supply; and

determining the limited set of concentrations further comprises determining the limited set of concentration based at least in part on at least one of the maximum permissible concentration or the commercial premix concentration.

4. The method as recited in claim 1, further comprising sending output data that indicates the limited set of concentrations for drug supply to be used in continuous infusions.

5. The method as recited in claim 4, wherein sending the output data further comprises sending the output data that indicates instructions to a pharmacist for compounding the limited set of concentrations for drug supply to be used in continuous infusions.

6. The method as recited in claim 1, further comprising determining a set of patient weight and dosage combinations that are to use, during continuous infusions, a particular concentration for drug supply from the limited set of concentrations for drug supply.

7. The method as recited in claim 6, further comprising sending output data that indicates weight and dosage combinations that are to use, during continuous infusions, a particular concentrations for drug supply from the limited set of concentrations for drug supply.

8. The method as recited in claim 6, wherein:

receiving the patient data further comprises receiving patient data that indicates a maximum fluid load to be received by a patient during administration of the drug; and

the particular concentration does not cause a fluid load to exceed the maximum fluid load during continuous infusion for the set of patient weight and dosage combinations.

9. The method as recited in claim 6, further comprising sending output data that indicates, for a particular patient weight and dosage combination, a particular infusion rate at the particular concentration for drug supply.

10. The method as recited in claim 6, further comprising sending output data that indicates, for a particular patient weight and dosage combination, a particular fluid load for continuous infusion using the particular concentration for drug supply.

11. The method as recited in claim 1, further comprising:

receiving individual patient data that indicates a particular weight and a particular dose of the drug for a particular patient; and

determining a particular concentration for drug supply of the limited set of concentrations and a particular infusion rate based on the particular weight and particular dose; and

sending output data that indicates the particular concentration and the particular infusion rate.

12. The method as recited in claim 11, wherein:

receiving the individual patient data further comprises receiving the individual patient data that indicates a particular fluid goal; and

determining the particular concentration and the particular infusion rate is based at least in part on the particular fluid goal.

13. The method as recited in claim 11, wherein:

determining the particular concentration and the particular infusion rate further comprises determining a modification to the particular concentration for the drug supply; and

sending output data further comprises sending output data that indicates the modification to the particular concentration for the drug supply.

14. The method as recited in claim 1, wherein the patients is include a pediatric patient.

15. A computer-readable external mass storage carrying a computer program for determining supply concentrations of a drug to administer to a patient as a continuous infusion, wherein execution of the computer program by a microprocessor causes the microprocessor to:

receive drug data that indicates an entire dose range between a minimum effective dose for a drug and a maximum allowable dose for the drug;

receive patient data that indicates a range of patient weights of patients to be treated with the drug;

receive pump data that indicates a minimum infusion rate of an infusion pump; and

determine, based on the drug data, the patient data and the pump data, a limited set of concentrations for drug supply that are used in continuous infusions for the entire range of patient weights across the entire dose range between the minimum effective dose for the drug and the maximum allowable dose for the drug,

wherein the limited set of concentrations contains two to four optimal concentrations.

16. An apparatus for determining supply concentrations of a drug to administer to a patient as a continuous infusion, comprising:

means for receiving drug data that indicates an entire dose range between a minimum effective dose for a drug and a maximum allowable dose for the drug;

means for receiving patient data that indicates a range of patient weights of patients to be treated with the drug;

means for receiving pump data that indicates a minimum infusion rate of an infusion pump; and

means for determining, based on the drug data, the patient data and the pump data, a limited set of concentrations for drug supply that are used in continuous infusions for the entire range of patient weights across the entire dose range between the minimum effective dose for the drug and the maximum allowable dose for the drug,

wherein the limited set of concentrations contains two to four optimal concentrations.

17. An apparatus for determining supply concentrations of a drug to administer to a patient as a continuous infusion, comprising:

one or more microprocessors;

a display;

a computer-readable internal memory or external mass storage; and

a computer program stored on the computer-readable memory or external mass storage,

wherein execution of the computer program by the one or more microprocessors causes the one or more microprocessors to

receive drug data that indicates an entire dose range between a minimum effective dose for a drug and a maximum allowable dose for the drug;

receive patient data that indicates a range of patient weights of patients to be treated with the drug;

receive pump data that indicates a minimum infusion rate of an infusion pump;

determine, based on the drug data, the patient data and the pump data, a limited set of concentrations for drug supply that are used in continuous infusions for the entire range of patient weights across the entire dose range between the minimum effective dose for the drug and the maximum allowable dose for the drug; and

present data indicating the limited set of concentrations for drug supply on the display wherein the limited set of concentrations contains two to four optimal concentrations.