System and method of treating stuttering by neuromodulation

• US 7,815,597 B2
• Filed: 06/27/2005
• Issued: 10/19/2010
• Est. Priority Date: 10/31/2001
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Stypulkowski, Paul H.
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US11/168,604
• Publication Number:
  US 20060041221A1
• Time in Patent Office: 1,940 Days
• Field of Search: 604/890.1, 604/891.1, 604/93.01, 604/528, 604502-503, 604/66, 604/43, 604/500, 604/67, 607/48, 607/118, 607/45, 128/899, 600/23, 600/544, 600/546
• US Class Current: 604/67
• CPC Class Codes: A61F 5/58 Apparatus for correcting stammering or stuttering
• CPC Class Codes: A61M 2210/0693 Brain, cerebrum
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

Stuttering-treatment techniques using neural stimulation and/or drug delivery. One or more electrodes and/or a catheter are implanted adjacent to sites in the brain. A signal generator and the electrode deliver stimulation to a first site. A pump and the catheter deliver one or more therapeutic drugs to a second site. The first and second sites could be: the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, or other paramedian thalamic and midbrain nuclei. The stuttering treatment could be performed via periodic transcranial magnetic stimulation. A sensor, located near the patient'"'"'s vocal folds, can be used for generating a signal responsive to activity of the patient'"'"'s speech-producing muscles. A controller adjusts one or more stimulation parameters in response to the signal from the sensor.

Claims

1. A method for therapeutically treating stuttering in a patient having a vocal fold, comprising:

delivering a drug using a pump and at least one catheter having a proximal end coupled to the pump and having a discharge end adjacent to a predetermined site in the brain selected from a group consisting of the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, the red nucleus, the habenulointerpeduncular tract, the prerubral area, the zona incerta, the thalamic primary sensory relay nuclei, the parafasicular nucleus, and the intralaminar nucleus;

generating a signal responsive to activity of the patient'"'"'s speech-producing muscles using a sensor positioned near the vocal fold of the patient; and

regulating dosage of the drug using a controller in response to the signal from the sensor to reduce activity, corresponding to stuttering, of the patient'"'"'s speech-producing muscles.

2. The method of claim 1, wherein the sensor is an electromyographic sensor.

3. The method of claim 1, wherein the sensor is an electroglottographic sensor.

4. The method of claim 1, wherein the controller discharges the drug dosage at a first rate at times when the patient is expected to be awake, and at a second rate when the patient is expected to be asleep, the second rate being reduced relative to the first rate.

5. The method of claim 1, further comprising:

delivering electrical stimulation to at least one predetermined electrical stimulation site of the patient'"'"'s brain using a signal generator and at least one implantable lead coupled to the signal generator.

6. The method of claim 5, further comprising using a controller to perform speech-recognition processing on the signal from the sensor to detect stuttering and to adjust at least one stimulation parameter of the electrical stimulation in response to detecting stuttering.

7. The method of claim 5, further comprising using a controller to detect when the patient starts speaking and to start the electrical stimulation in response to detecting that the patient has started to speak.

8. The method of claim 5, further comprising using a controller to stop the electrical stimulation a predetermined amount of time after the patient has started to speak.

9. A method for therapeutically treating stuttering in a patient having a vocal fold comprising:

delivering a drug using a pump and at least one catheter having a proximal end coupled to the pump and having a discharge end adjacent to a predetermined site in the brain selected from a group consisting of the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, the red nucleus, the habenulointerpeduncular tract, the prerubral area, the zona incerta, the thalamic primary sensory relay nuclei, the parafasicular nucleus, and the intralaminar nucleus;

generating a signal indicative of speech-producing muscle activity of the patient using a sensor positioned near the vocal fold of the patient; and

regulating dosage of the drug using a controller responsive to the signal from the sensor to reduce activity, corresponding to stuttering, of the patient'"'"'s speech-producing muscles.

10. A method for therapeutically treating stuttering in a patient comprising:

delivering at least one drug using a pump and at least one catheter having a proximal end coupled to the pump and having a discharge end adjacent to a predetermined drug delivery site in the brain selected from a group consisting of the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, the red nucleus, the habenulointerpeduncular tract, the prerubral area, the zona incerta, the thalamic primary sensory relay nuclei, the parafasicular nucleus, and the intralaminar nucleus;

regulating drug dosage using a controller responsive to circadian rhythms to reduce stuttering, wherein the regulating comprises;

discharging the at least one drug to the predetermined site at a first rate at times when the patient is expected to be awake, and

discharging the at least one drug to the predetermined site at a second rate when the patient is expected to be asleep, the second rate being reduced relative to the first rate.

11. The method of claim 10 further comprising:

delivering electrical stimulation to at least one predetermined electrical stimulation site of the patient'"'"'s brain using a signal generator and at least one implantable lead coupled to the signal generator.

12. The method of claim 11 further comprising:

using a sensor, generating a signal indicative of activity of the patient'"'"'s speech-producing muscles; and

using a controller that performs speech-recognition processing on the signal from the sensor to detect stuttering and to adjust at least one stimulation parameter of the electrical stimulation in response to detecting stuttering.

13. The method of claim 12, wherein the sensor is an electromyographic sensor.

14. The method of claim 12, wherein the sensor is an electroglottographic sensor.

15. The method of claim 12, further comprising detecting, by the controller, when the patient starts speaking and starting the electrical stimulation in response to detecting that the patient has started to speak.

16. The method of claim 15, further comprising stopping, by the controller, the electrical stimulation a predetermined amount of time after the patient has started to speak.

17. The method of claim 11 further comprising:

generating a signal responsive to activity of the patient'"'"'s speech-producing muscles using a sensor; and

using a controller that includes a speech-recognition module, performing speech-recognition processing on the signal from the sensor to detect stuttering and to adjust at least one stimulation parameter in response to detecting stuttering.

18. The method of claim 17, wherein the sensor is a microphone.

19. The method of claim 18, wherein the microphone is human-implantable.

20. The method of claim 17, wherein performing the speech-recognition processing to detect stuttering further comprises detecting a predetermined number of repetitions of a speech pattern.

21. A method for therapeutically treating stuttering in a patient having a vocal fold comprising:

delivering a drug using a pump and at least one catheter having a proximal end coupled to the pump and a discharge end adjacent to a predetermined drug delivery site in the brain selected from a group consisting of the supplementary motor area, the centromedian circuit, the dorsomedial nuclei, the lateral prefrontal circuit, the red nucleus, the habenulointerpeduncular tract, the prerubral area, the zona incerta, the thalamic primary sensory relay nuclei, the parafasicular nucleus, and the intralaminar nucleus;

delivering electrical stimulation to at least one predetermined electrical stimulation site of the patient'"'"'s brain using a signal generator and at least one implantable lead coupled to the signal generator;

generating a signal indicative of activity of the patient'"'"'s speech-producing muscles using a sensor located in proximity to the vocal fold of the patient; and

using a controller to adjust at least one stimulation parameter of the electrical stimulation in response to the signal.

22. The method of claim 21 wherein the controller includes a speech-recognition module for performing speech-recognition processing on the signal from the sensor to detect stuttering and to adjust at least one stimulation parameter in response to detecting stuttering.

23. The method of claim 21, wherein the controller detects when the patient starts speaking and starts the electrical stimulation in response to detecting that the patient has started to speak.

24. The of claim 23, wherein the controller stops the electrical stimulation a predetermined amount of time after the patient has started to speak.

25. The method of claim 21, wherein the sensor is an electromyographic sensor.

26. The method of claim 21, wherein the sensor is an electroglottographic sensor.

27. The method of claim 21, wherein the sensor is a microphone.

28. The method of claim 27, wherein the microphone is human-implantable.