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Method for activating efferent sympathetic nerves innervating adipose tissues to improve obesity and symptoms associated therewith

  • US 7,815,895 B2
  • Filed: 05/21/2007
  • Issued: 10/19/2010
  • Est. Priority Date: 05/21/2007
  • Status: Active Grant
First Claim
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1. A method for screening for a substance for weight reduction, comprising the steps of:

  • screening for a substance that excites an afferent vagal nerve from the liver, wherein the substance is comprised in culture supernatant of a hepatocyte in which PPARγ

    2 is overexpressed; and

    examining if the substance can suppress weight gain or obesity in an animal.

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