Implantable graft material
First Claim
1. An isolated graft material retaining a valve cusp shape for providing a valve cusp for contacting and modifying fluid flow in a body passageway, said isolated graft material prepared by a process comprising removing from a body cavity of a host a tissue material resulting from remodeling of a previously inserted amount of a remodelable extracellular matrix material in the body cavity, the remodelable extracellular matrix material being associated with an implanted shaping element in the body cavity and being effective, upon insertion in said body cavity, to stimulate the ingrowth of native cells into the remodelable extracellular matrix material such that the remodelable extracellular matrix material becomes infiltrated and replaced by newly formed host tissue, wherein said remodeling of said previously inserted amount of remodelable extracellular matrix material in association with said implanted shaping element causes said graft material to retain said valve cusp shape.
1 Assignment
0 Petitions
Accused Products
Abstract
Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient'"'"'s body.
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Citations
53 Claims
- 1. An isolated graft material retaining a valve cusp shape for providing a valve cusp for contacting and modifying fluid flow in a body passageway, said isolated graft material prepared by a process comprising removing from a body cavity of a host a tissue material resulting from remodeling of a previously inserted amount of a remodelable extracellular matrix material in the body cavity, the remodelable extracellular matrix material being associated with an implanted shaping element in the body cavity and being effective, upon insertion in said body cavity, to stimulate the ingrowth of native cells into the remodelable extracellular matrix material such that the remodelable extracellular matrix material becomes infiltrated and replaced by newly formed host tissue, wherein said remodeling of said previously inserted amount of remodelable extracellular matrix material in association with said implanted shaping element causes said graft material to retain said valve cusp shape.
- 9. A method of forming an isolated graft material suitable for implantation in the body of a patient, the method comprising removing from a body cavity of a host a tissue material resulting from remodeling of a previously inserted amount of a remodelable extracellular matrix material in the body cavity, the remodelable extracellular matrix material being associated with an implanted shaping element in the body cavity and being effective, upon insertion in said body cavity, to stimulate the ingrowth of native cells into the remodelable extracellular matrix material such that the remodelable extracellular matrix material becomes infiltrated and replaced by newly formed host tissue, wherein said remodeling of said previously inserted amount of remodelable extracellular matrix material in association with said implanted shaping element causes said tissue material to retain a valve cusp shape for providing a valve cusp for contacting and modifying fluid flow in a body passageway, or an elongate generally cylindrical shape having a generally solid cross section for providing a prosthetic ligament or tendon.
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15. A method of forming an isolated, decellularized tissue material, the method comprising:
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removing from a body cavity of a host a tissue material resulting from remodeling of a previously inserted amount of a remodelable extracellular matrix material in the body cavity, the remodelable extracellular matrix material being effective, upon insertion in said body cavity, to stimulate the ingrowth of native cells into the remodelable extracellular matrix material such that the remodelable extracellular matrix material becomes infiltrated and replaced by newly formed host tissue; and decellularizing the tissue material following removal from said body cavity. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
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- 48. An isolated tissue material suitable for implantation in the body of a patient, said isolated tissue material prepared by a process comprising removing from a body cavity of a host a tissue material resulting from remodeling of a previously inserted amount of a remodelable extracellular matrix material in the body cavity, the remodelable extracellular matrix material being associated with an implanted shaping element in the body cavity and being effective, upon insertion in said body cavity, to stimulate the ingrowth of native cells into the remodelable extracellular matrix material such that the remodelable extracellular matrix material becomes infiltrated and replaced by newly formed host tissue, wherein said remodeling of said previously inserted amount of remodelable extracellular matrix material in association with said implanted shaping element causes said tissue material to retain a valve cusp shape for providing a valve cusp for contacting and modifying fluid flow in a body passageway, or an elongate generally cylindrical shape having a generally solid cross section for providing a prosthetic ligament or tendon.
Specification