Detection, diagnosis, and monitoring of a medical condition or disease with artificial olfactometry
First Claim
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1. A method of determining a physiological condition in a mammal, said method comprising the steps of:
- placing an array of sensors in contact with a sample from a mammal suspected of having a physiological condition to generate a sensor array response profile;
identifying the sensor array response profile in order to determine whether there exists a clinical diagnostic marker for the physiological condition; and
receiving, by a data processor, the sensor array response profile output by the array of sensors and an output of the identifying step, and developing a diagnosis using said sensor array response profile in combination with the output of the identifying step, thereby detecting whether or not there exists the physiological condition,wherein the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, andwherein the sensor array response profile is generated by the steps of;
a) measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and
b) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and
c) generating the sensor array response profile based on the first and second responses.
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Abstract
Methods and devices for rapid diagnosis and monitoring a patient for disease or effectiveness of treatment in real time. In preferred embodiments, the methods and devices comprise contacting an array of sensors with a sample from a mammal suspected of having a disease to generate a sensor array profile, measuring a clinical diagnostic marker for the suspected disease, and then developing a diagnosis using the sensor array profile in combination with the clinical diagnostic marker.
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Citations
10 Claims
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1. A method of determining a physiological condition in a mammal, said method comprising the steps of:
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placing an array of sensors in contact with a sample from a mammal suspected of having a physiological condition to generate a sensor array response profile; identifying the sensor array response profile in order to determine whether there exists a clinical diagnostic marker for the physiological condition; and receiving, by a data processor, the sensor array response profile output by the array of sensors and an output of the identifying step, and developing a diagnosis using said sensor array response profile in combination with the output of the identifying step, thereby detecting whether or not there exists the physiological condition, wherein the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, and wherein the sensor array response profile is generated by the steps of; a) measuring a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and b) measuring a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration; and c) generating the sensor array response profile based on the first and second responses. - View Dependent Claims (2, 3, 7, 8)
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4. A system for determining a physiological condition in a mammal, said system comprising:
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an array of sensors placed in contact with a sample from a mammal suspected of having a physiological condition to generate a sensor array response profile; a data processor that receives the sensor array response profile and that determines whether or not there exists a clinical diagnostic marker for the physiological condition; and wherein the data processor develops, based on the sensor array response profile output by the array of sensors and the determination by the data processor as to whether or not the clinical diagnostic marker exists, a diagnosis, thereby detecting whether or not there exists the physiological condition in the mammal; and a measuring device that measures the sensor array response profile from sensor signals output by the array of sensors, wherein the array of sensors includes a chemical sensor electrically coupled to first and second conductive leads, and wherein the measuring device; measures a first response between the first and second conductive leads when the chemical sensor is contacted with a first marker gas at a first concentration; and measures a second response between the first and second conductive leads when the chemical sensor is contacted with the first marker gas at a second concentration different from the first concentration. - View Dependent Claims (5, 6, 9, 10)
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Specification