Modulation and analysis of cerebral perfusion in epilepsy and other neurological disorders
First Claim
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1. An implantable device for responding to a neurological disorder in a human patient and configured to be implanted in the human patient, comprising:
- a detection subsystem coupled to at least one sensor,wherein the sensor is adapted to generate a signal representative of a cerebral perfusion measurement, andwherein the detection subsystem is adapted to receive and process the signal at predetermined times;
a processor adapted to identify automatically a condition in the signal and adapted to generate automatically an instruction for therapy based on the identified condition, wherein the condition is a predetermined change in cerebral perfusion; and
a subsystem in operative communication with the processor and adapted to provide a therapy to the human patient in response to the condition when instructed by the processor, wherein the therapy is intended to return cerebral perfusion measurement to a desired value or range of values.
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Abstract
A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.
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Citations
67 Claims
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1. An implantable device for responding to a neurological disorder in a human patient and configured to be implanted in the human patient, comprising:
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a detection subsystem coupled to at least one sensor, wherein the sensor is adapted to generate a signal representative of a cerebral perfusion measurement, and wherein the detection subsystem is adapted to receive and process the signal at predetermined times; a processor adapted to identify automatically a condition in the signal and adapted to generate automatically an instruction for therapy based on the identified condition, wherein the condition is a predetermined change in cerebral perfusion; and a subsystem in operative communication with the processor and adapted to provide a therapy to the human patient in response to the condition when instructed by the processor, wherein the therapy is intended to return cerebral perfusion measurement to a desired value or range of values. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
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64. A system for responding to a neurological disorder in a human patient, comprising:
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a control unit implantable in the patient and comprising a detection subsystem coupled to at least one sensor, wherein the sensor is adapted to generate a signal representative of a cerebral perfusion measurement, and wherein the detection subsystem is adapted to regularly receive and process the signal; a processor operatively coupled to the control unit and adapted to receive the signal and automatically identify a condition in the signal corresponding to an abnormal cerebral perfusion level; and a therapy subsystem operatively coupled to the processor and to at least one therapy output, wherein the therapy subsystem is adapted to selectively initiate delivery of a therapy to the therapy output when the condition is identified in the signal and wherein the therapy is intended to normalize the cerebral perfusion level. - View Dependent Claims (65, 66, 67)
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Specification