System and methods for administering bioactive compositions

• US 7,819,847 B2
• Filed: 09/16/2005
• Issued: 10/26/2010
• Est. Priority Date: 06/10/2003
• Status: Expired due to Fees

• Current Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Original Assignee: Hewlett-Packard Development Company, L.P. (HP Inc.)
• Inventors: Vitello, Christopher John, Greeven, John C., Welkley, Stephen R., Evans, Andrew L
• Primary Examiner(s): Mendez; Manuel A
• Application Number:
  US11/228,884
• Publication Number:
  US 20060031099A1
• Time in Patent Office: 1,866 Days
• Field of Search: 604 65- 67, 604/131, 604/253, 128/DIG.12, 128/DIG.13
• US Class Current: 604/253
• CPC Class Codes: A61M 15/025 Bubble jet droplet ejection devices
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14212 Pumping with an aspiration and an expulsion action
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/1689 Drip counters
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G16H 20/13 delivered from dispensers
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

Bioactive agents are dosed by a jet dispenser using inkjet technology, such as that used in printing devices. A controller may control delivery of one or more drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient or information received from other nodes in a healthcare system. In a healthcare system, smart devices coupled to healthcare nodes can be in communication with the controller for controlling the administration of bioactive compositions from the jet dispenser.

Claims

1. A healthcare system for administering a bioactive composition to a subject, comprising:

an infusion drug delivery device;

a first smart device integral with and coupled to the drug delivery device;

a second smart device coupled to a healthcare node of the healthcare system, wherein the first smart device and the second smart device are operable to communicate with each other information for the administration of the bioactive composition, and wherein the first smart device is configured to automatically create a patient-specific variable drug dosage instruction based at least upon the information received from the second smart device; and

at least one jet dispenser of the drug delivery device configured to be operable in accordance with the patient-specific variable drug dosage instruction.

2. The system of claim 1, wherein the drug delivery device further comprises a fluid manifold having at least one mixing chamber, the at least one mixing chamber being configured to receive the bioactive composition dispensed from the at least one jet dispenser, the at least one mixing chamber having an inlet for receiving an infusion liquid to be mixed with the bioactive composition and an outlet for discharging a mixture of the infusion liquid and the bioactive composition.

3. The system of claim 1, wherein the drug delivery device further comprises at least one mixing chamber, comprising:

a drip surface;

a first inlet for receiving an infusion liquid oriented such that the infusion liquid is directed onto the drip surface;

a second inlet for receiving the bioactive composition dispensed from the at least one jet dispenser such that the bioactive composition is directed onto the drip surface; and

a fluid outlet for discharging the mixture of the infusion liquid and the bioactive composition.

4. The system of claim 1, wherein the drug delivery device further comprises at least one fluid reservoir for containing the bioactive composition, the at least one fluid reservoir being fluidly connected to the respective at least one jet dispenser.

5. The system of claim 1, wherein the drug delivery device further comprises at least one drop detector operable to detect at least one characteristic of the droplets of the bioactive composition that are dispensed from the at least one jet dispenser and provide a signal corresponding to the detected at least one characteristic.

6. The system of claim 5, wherein the at least one drop detector is operable to detect a presence of droplets dispensed from the at least one jet dispenser.

7. The system of claim 5, wherein the at least one drop detector is operable to detect a rate at which the drops are ejected from the at least one jet dispenser.

8. The system of claim 5, wherein the at least one drop detector is operable to detect a volume of the droplets dispensed from the at least one jet dispenser.

9. The system of claim 5, wherein the drug delivery device further comprises an alarm operatively connected to the at least one drop detector and operable to provide a warning if the at least one characteristic detected by the drop detector does not satisfy a predetermined condition.

10. The system of claim 9, wherein the alarm provides a warning if the at least one drop detector does not detect the presence of droplets.

11. The system of claim 5, wherein the first smart device comprises a controller operable to control the at least one jet dispenser to dispense the bioactive composition.

12. The system of claim 11, wherein the controller is in communication with the at least one drop detector.

13. The system of claim 11, wherein the controller is operable to automatically shut off the drug delivery device when the information does not comply with predetermined safety standards.

14. The system of claim 1, wherein the at least one jet dispenser comprises a piezoelectric droplet jet dispenser.

15. The system of claim 1, wherein the at least one jet dispenser comprises a thermal droplet jet dispenser.

16. The system of claim 1, wherein the first smart device comprises a smart chip.

17. The system of claim 1, wherein the second smart devise comprises a smart chip.

18. The system of claim 17, wherein the health care node comprises a human body and the second smart device is embedded within the human body.

19. The system of claim 17, further comprising a wearable mounting device for mounting the second smart device.

20. The system of claim 19, wherein the mounting device comprises a band adapted to be worn by a person.

21. The system of claim 1, wherein the healthcare node comprises a person.

22. The system of claim 21, wherein the person comprises at least one person selected from the group consisting of:

a patient;

a doctor;

a nurse;

a pharmacist; and

a laboratory technician.

23. The system of claim 1, wherein the healthcare node comprises a computer system.

24. The system of claim 23, wherein the computer system comprises at least one system selected from the group consisting of:

a decision support system;

a electronic medical record system; and

a medical payment provider system.

25. The system of claim 1, wherein the healthcare node comprises at least one node selected from the group consisting of:

a fluid reservoir for containing the bioactive composition; and

a medical device.

26. The system of claim 25, wherein the medical device is operable to detect patient vital signs.

27. The system of claim 1, wherein the information for the administration of the bioactive composition comprises at least one type of data selected from the group consisting of:

bioactive composition data;

patient or health professional data;

computerized support system data; and

medical device data.

28. The system of claim 27, wherein the information for the administration of the bioactive composition is stored on a computer system to create a health history for the subject.

29. The system of claim 27, wherein the bioactive composition data comprises at least one type of data selected from the group consisting of:

fluid reservoir data;

bioactive composition identification data;

bioactive composition dosage amount data;

bioactive composition dosage rate data;

bioactive composition dosage frequency data; and

bioactive composition dosage ratio data.

30. The system of claim 29, wherein the fluid reservoir data comprises at least one type of data selected from the group consisting of:

bioactive composition safety data;

bioactive composition expiration date data;

bioactive composition expiration time data;

prescribed bioactive composition dosage amount data;

prescribed bioactive composition dosage rate data;

prescribed bioactive composition dosage frequency data; and

prescribed bioactive composition dosage ratio data.

31. The system of claim 27, wherein the patient or healthcare professional data comprises at least one type of data selected from the group consisting of:

patient identification data;

doctor identification data;

nurse identification data; and

pharmacist identification data.

32. The system of claim 27, wherein the computerized support system data comprises as least one type of data selected from the group consisting of:

payment provider information;

patient medical information; and

decision support system information.

33. The system of claim 27, wherein the medical device data comprises patient vital signs data.

34. They system of claim 27, wherein the medical device data comprises an alarm signal.

35. A method for administering a bioactive composition to a subject from an infusion drug delivery device having at least one jet dispenser, comprising:

detecting, via a smart device integral with and coupled to the drug delivery device, at least one smart device coupled to a healthcare node;

receiving information from the at least one smart device relating to the administration of the bioactive composition;

creating, via the smart device coupled to the drug delivery device, a subject-specific variable drug dosage instruction for the administration of the bioactive composition to the subject based on the information received;

communicating the subject-specific variable drug dosage instruction to the at least one jet dispenser of the drug delivery device; and

dispensing the bioactive composition from at least one jet dispenser of the drug delivery device in accordance with the subject-specific variable drug dosage instruction.

36. The method of claim 35, wherein the at least one smart device coupled to the healthcare node comprises a smart chip.

37. The method of claim 35, wherein the drug delivery device further comprises a controller operable to control the at least one jet dispenser to dispense the bioactive composition.

38. The method of claim 35, wherein detecting the at least one smart device coupled to the healthcare node comprises detecting the at least one smart device via wireless communication.

39. The method of claim 35, wherein the act of receiving information comprises receiving information via wireless communication.

40. The method of claim 35, wherein the at least one healthcare node comprises at least one node selected from the group consisting of:

a person;

a computer system;

a fluid reservoir for containing the bioactive composition; and

a medical device.

41. The method of claim 35, wherein the information received from the at least one smart device coupled to the healthcare node comprises at least one type of data selected from the group consisting of:

bioactive composition data;

patient or healthcare professional data;

computerized support system data; and

medical device data.

42. The method of claim 35, further comprising creating a health history for the subject from the information received from the at least one smart device coupled to the healthcare node.

43. The method of claim 35, wherein creating the subject-specific variable drug dosage instruction comprises:

analyzing the information received from the at least one smart device coupled to the healthcare node; and

creating the subject-specific variable drug dosage instruction based on the analyzing.

44. The method of claim 43, wherein the act of analyzing the information received comprises comparing the information received.

45. The method of claim 43, wherein the act of creating the subject-specific variable drug dosage instruction comprises:

determining whether the information satisfies predetermined safety standards; and

creating the subject-specific variable drug dosage instruction based upon the act of determining whether the information satisfies predetermined safety standards.

46. The method of claim 45, further comprising customizing the subject-specific variable drug dosage instruction for the subject based on the information received.

47. The method of claim 45, wherein the act of creating the subject-specific variable drug dosage instruction based upon the act of determining whether the information satisfies predetermined safety standards comprises generating instructions to stop dispensing the bioactive composition from the drug delivery device if safety standards are not met.

48. The method of claim 45, wherein the act of creating the subject-specific variable drug dosage instruction based upon the act of determining whether the information satisfies predetermined safety standards comprises generating instruction to dispense the bioactive compositions from the drug delivery device if safety standards are met.

49. The method of claim 35, wherein the act of creating a health history of a subject comprises storing the administration instructions on a computer system.

50. The method of claim 35, wherein the act of communicating the subject-specific variable drug dosage instruction comprises communicating the subject-specific variable drug dosage instruction via wireless communication.