Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
First Claim
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1. A method for converting a prodrug to an active form, comprising:
- administering a Nissle strain Escherichia coli bacteria to a subject, wherein Nissle bacterium encodes a prodrug converting enzyme for converting a prodrug into an active form; and
administering a prodrug that is converted by the enzyme, whereby an active form of the prodrug is produced.
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Abstract
Methods for detecting a microorganism or cell in a subject and methods for detecting, imaging or diagnosing a site, disease, disorder or condition in a subject using microorganisms or cells and methods that microorganisms or cells for treating a disease, disorder or condition are provided. Sites, diseases and disorders include sites of cell proliferation, proliferative conditions, neoplasms, tumors, neoplastic disease, wounds and inflammation. Also provided are microorganisms and cells for use in the methods and compositions, combinations and kits, including diagnostic and pharmaceutical compositions, containing a microorganism or cell.
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Citations
18 Claims
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1. A method for converting a prodrug to an active form, comprising:
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administering a Nissle strain Escherichia coli bacteria to a subject, wherein Nissle bacterium encodes a prodrug converting enzyme for converting a prodrug into an active form; and administering a prodrug that is converted by the enzyme, whereby an active form of the prodrug is produced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification