Polymer for use in conduits, medical devices and biomedical surface modification
First Claim
1. A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different,wherein said one or more pendant group segments are the same or different and are siloxane segments, wherein each of said siloxane segments comprises a siloxane moiety which is either a linear siloxane with a molecular weight of up to 2000 Daltons, a silsesquioxane cage or a partial silsesquioxane cage, said moiety being attached to the copolymer backbone either directly or via a pendant arm that does not contain any ether groups, and wherein when said moiety is a silsesquioxane cage or partial silsesquioxane cage, then the molar ratio of pendant group segments to polyol segments is 1:
- X wherein X is 10 or more, and wherein when said moiety is a linear siloxane, then the component (b) comprises one or more polycarbonate segments.
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Accused Products
Abstract
A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different,
wherein said one or more pendant group segments are the same or different and are selected from:
- (i) siloxane segments;
- (ii) segments containing phosphoryl choline or a derivative or analogue thereof;
- (iii) segments containing a di- or trifluoromethyl group;
- (iv) heparin-like segments containing a group of formula (XII)
D-N═N—Ar—SO3− (XII)
wherein D is an aliphatic or aromatic group and Ar—SO3− comprises one or more linked aryl and/or heteroaryl groups, at least one of the aryl and/or heteroaryl groups having an SO3− substituent; and - (v) segments containing a group of formula (I)
[P]n′-[Lys]n-Lys-[Spacer]-Lys-[Al]x (I)
wherein:- [Al] is an inert amino acid;
- x is 0, 1, 2 or 3;
- [Spacer] is a fatty acid, amino acid, peptide or PEG;
- [P]n′-[Lys]n is a dendritic structure formed from n lysine groups and terminating in n′ groups P;
- n is an integer of from 1 to 15;
- n′ is zero or an integer of up to 16; and
- each P is the same or different and is an amino acid or a peptide having up to 25 amino acids,
and wherein at least a part of each of said pendant group segment(s) is on a side chain of the copolymer.
The copolymer is useful in the production of implantable devices such as vascular grafts.
27 Citations
38 Claims
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1. A copolymer comprising (a) one or more pendant group segments and (b) one or more polyol segments, each of said segments being linked to one or more further segments which may be the same or different,
wherein said one or more pendant group segments are the same or different and are siloxane segments, wherein each of said siloxane segments comprises a siloxane moiety which is either a linear siloxane with a molecular weight of up to 2000 Daltons, a silsesquioxane cage or a partial silsesquioxane cage, said moiety being attached to the copolymer backbone either directly or via a pendant arm that does not contain any ether groups, and wherein when said moiety is a silsesquioxane cage or partial silsesquioxane cage, then the molar ratio of pendant group segments to polyol segments is 1: - X wherein X is 10 or more, and wherein when said moiety is a linear siloxane, then the component (b) comprises one or more polycarbonate segments.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
Specification