Tumor necrosis factor-gamma
First Claim
1. An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
- (a) a protein whose amino acid sequence consists of amino acid residues 1 to 35 of SEQ ID NO;
20;
(b) a protein whose amino acid sequence consists of amino acid residues 36 to 61 of SEQ ID NO;
20; and
(c) a protein whose amino acid sequence consists of amino acid residues 1 to 100 of SEQ ID NO;
20.
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Accused Products
Abstract
Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
119 Citations
20 Claims
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1. An isolated antibody or fragment thereof that specifically binds to a protein selected from the group consisting of:
-
(a) a protein whose amino acid sequence consists of amino acid residues 1 to 35 of SEQ ID NO;
20;(b) a protein whose amino acid sequence consists of amino acid residues 36 to 61 of SEQ ID NO;
20; and(c) a protein whose amino acid sequence consists of amino acid residues 1 to 100 of SEQ ID NO;
20. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An isolated antibody or fragment thereof that specifically binds a tumor necrosis factor-gamma protein purified from a cell culture wherein said tumor necrosis factor-gamma protein is encoded by a polynucleotide encoding amino acids 1 to 251 of SEQ ID NO:
- 20; and
wherein said antibody or fragment thereof specifically binds to a protein selected from the group consisting of;(a) a protein whose amino acid sequence consists of amino acid residues 1 to 35 of SEQ ID NO;
20;(b) a protein whose amino acid sequence consists of amino acid residues 36 to 61 of SEQ ID NO;
20; and(c) a protein whose amino acid sequence consists of amino acid residues 1 to 100 of SEQ ID NO;
20. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
- 20; and
Specification