Modified carbocyanine dyes and their conjugates
First Claim
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1. A method of staining a biological sample, comprising:
- combining a dye solution comprising a compound having the formula;
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Abstract
Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
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8 Claims
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1. A method of staining a biological sample, comprising:
combining a dye solution comprising a compound having the formula; - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for forming a dye-conjugate of a protein, peptide or a nucleic acid polymer, said method comprising:
combining a dye solution comprising a compound of the formula - View Dependent Claims (8)
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