Method for determining the left-ventricular ejection time TLVE of a heart of a subject

• US 7,822,470 B2
• Filed: 10/09/2002
• Issued: 10/26/2010
• Est. Priority Date: 10/11/2001
• Status: Active Grant

• Current Assignee: Osypka Medical GmbH
• Original Assignee: Osypka Medical GmbH
• Inventors: Osypka, Markus J., Bernstein, Donald P.
• Primary Examiner(s): Evanisko; George R
• Assistant Examiner(s): ALTER, ALYSSA MARGO
• Application Number:
  US10/267,313
• Publication Number:
  US 20030163058A1
• Time in Patent Office: 2,939 Days
• Field of Search: 607/24, 607/8, 607/88, 607/17, 607/18, 600/513, 600/547, 600/504, 600/505, 600/323, 600453-456
• US Class Current: 600/513
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

In order to reliably determine the left-ventricular ejection time T_LVE of a heart of a subject, at least two different measuring methods are employed. This includes in any case the derivation of a first waveform related to thoracic electrical bioimpedance or bioadmittance. A second waveform can be determined by using pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure and measurement of peripheral electrical bioimpedance or bioadmittance. Depending on signal quality, the results obtained by each method are weighted and then averaged. The weighted average for left-ventricular ejection time is used as an input variable for cardiovascular monitoring methods, which determine objective measurements of cardiovascular function and performance. Such measurements include, but are not limited to, left ventricular ejection fraction, stroke volume, cardiac output, systolic time ratio, and indices of ventricular contractility.

Claims

1. A method of determining the left-ventricular ejection time T_LVE of a heart of a subject, comprising:

deriving a first waveform for determining T_LVE including measuring a value selected from the group consisting of thoracic electrical bioimpedance and thoracic electrical bioadmittance over time;

deriving at least a second waveform for determining T_LVE by using a method selected from the group consisting of pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure, measurement of peripheral electrical bioimpedance, and measurement of peripheral electrical bioadmittance; and

a) in a first action, independently using said first waveform and said at least a second waveform to determine values of T_LVE by applying predetermined criteria to define an opening point and a closure point of the aortic valve in said first waveform and said at least a second waveform, and

b) in a second action, averaging the values of T_LVE by using predetermined weights for the T_LVE values obtained from said first waveform and said at least a second waveform.

2. The method according to claim 1, wherein said second waveform is derived by using pulse oximetry.

3. The method according to claim 1, wherein said second waveform is derived by using pulse oximetry, and wherein said pulse oximetry measures the intensity of light absorbed by a finger of the subject, wherein light is emitted at one side of the finger and light is detected at the other side of the finger.

4. The method according to claim 3, wherein two wavelengths of light are utilized in pulse oximetry, the first wavelength being in the red band and the second wavelength being in the infrared band.

5. The method according to claim 1, wherein said second waveform is derived by using Doppler velocimetry.

6. The method according to claim 5, wherein a Doppler velocimeter is applied to a radial artery of the subject.

7. The method according to claim 1, wherein said second waveform is derived by using esophageal Doppler velocimetry.

8. The method according to claim 7, wherein the deriving of said first waveform comprises placing at least two electrodes on a catheter and inserting said catheter into the esophagus of the subject, and wherein the esophageal Doppler velocimetry is performed by using a transducer placed on said same catheter.

9. The method according to claim 1, wherein said second waveform is derived by using pulse oximetry, and wherein a third waveform is derived by using esophageal Doppler velocimetry, and wherein said first, second, and third waveforms are used to determine T_LVE.

10. The method according to claim 9, wherein the deriving of said first waveform comprises placing at least two electrodes on a catheter and inserting said catheter into the esophagus of the subject, and wherein the esophageal Doppler velocimetry is performed by using a transducer placed on said same catheter.

11. The method according to claim 1, wherein said second waveform is derived by using pulse oximetry, and wherein a third waveform is derived by using one of the group consisting of Doppler velocimetry at a radial artery of the subject, non-invasive measurement of blood pressure in a radial artery of the subject, and wherein said first, second, and third waveforms are used to determine T_LVE.

12. The method according to claim 1, wherein at least a third waveform is derived by using a method selected from the group consisting of pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure, measurement of peripheral electrical bioimpedance, and measurement of peripheral electrical bioadmittance, said at least a third waveform being derived by using the method that is different from the method used to derive said first and second waveforms, and wherein said first, second, and third waveforms are used to determine T_LVE.

13. The method according to claim 1, wherein:

a) predetermined criteria are used to independently define the opening point and the closure point of the aortic valves in of said waveforms,

b) said waveforms are aligned synchronously with time,

c) the opening points defined in said waveforms are used to derive an averaged opening point by using predetermined criteria,

d) the closure points defined in said waveforms are used to derive an averaged closure point by using predetermined criteria, and wherein

e) T_LVEis determined by calculating the time interval starting with said averaged opening point and ending at said averaged closure point.

14. The method according to claim 1, wherein an expectation window for T_LVEis established prior to precisely determining T_LVE.

15. The method according to claim 14, wherein said expectation window is established on the basis of a regression equation for T_LVE in dependence on the heart rate HR.

16. A method of determining the left-ventricular ejection time T_LVEof a heart of a subject, comprising:

deriving a first waveform for determining T_LVE including measuring a value selected from the group consisting of thoracic electrical bioimpedance and thoracic electrical bioadmittance over time;

deriving at least a second waveform for determining T_LVE by using a method selected from the group consisting of pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure, measurement of peripheral electrical bioimpedance, and measurement of peripheral electrical bioadmittance; and

a) using predetermined criteria to independently define an opening point and a closure point of the aortic valves in said first waveform and said at least a second waveform,

b) aligning said waveforms synchronously with time,

c) using the opening points defined in said waveforms to derive an averaged opening point by using predetermined criteria,

d) using the closure points defined in said waveforms to derive an averaged closure point by using predetermined criteria, and

e) determining T_LVE by calculating the time interval starting with said averaged opening point and ending at said averaged closure point.

17. The method according to claim 16, wherein said second waveform is derived by using pulse oximetry.

18. The method according to claim 16, wherein said second waveform is derived by using pulse oximetry, and wherein said pulse oximetry measures the intensity of light absorbed by a finger of the subject, wherein light is emitted at one side of the finger and light is detected at the other side of the finger.

19. The method according to claim 18, wherein two wavelengths of light are utilized in pulse oximetry, the first wavelength being in the red band and the second wavelength being in the infrared band.

20. The method according to claim 16, wherein said second waveform is derived by using Doppler velocimetry.

21. The method according to claim 20, wherein a Doppler velocimeter is applied to a radial artery of the subject.

22. The method according to claim 16, wherein said second waveform is derived by using esophageal Doppler velocimetry.

23. The method according to claim 22, wherein the deriving of said first waveform comprises placing at least two electrodes on a catheter and inserting said catheter into the esophagus of the subject, and wherein the esophageal Doppler velocimetry is performed by using a transducer placed on said same catheter.

24. The method according to claim 16, wherein said second waveform is derived by using pulse oximetry, and wherein a third waveform is derived by using esophageal Doppler velocimetry, and wherein said first, second, and third waveforms are used to determine T_LVE.

25. The method according to claim 24, wherein the deriving of said first waveform comprises placing at least two electrodes on a catheter and inserting said catheter into the esophagus of the subject, and wherein the esophageal Doppler velocimetry is performed by using a transducer placed on said same catheter.

26. The method according to claim 16, wherein said second waveform is derived by using pulse oximetry, and wherein a third waveform is derived by using one of the group consisting of Doppler velocimetry at a radial artery of the subject, non-invasive measurement of blood pressure in a radial artery of the subject, and wherein said first, second, and third waveforms are used to determine T_LVE.

27. The method according to claim 16, wherein at least a third waveform is derived by using a method selected from the group consisting of pulse oximetry, Doppler velocimetry, measurement of arterial blood pressure, measurement of peripheral electrical bioimpedance, and measurement of peripheral electrical bioadmittance, said at least a third waveform being derived by using the method that is different from the method used to derive said first and second waveforms, and wherein said first, second, and third waveforms are used to determine T_LVE.

28. The method according to claim 16, wherein an expectation window for T_LVE is established prior to precisely determining T_LVE.

29. The method according to claim 28, wherein said expectation window is established on the basis of a regression equation for T_LVE in dependence on the heart rate HR.