Higher fullerenes useful as radical scavengers
First Claim
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1. A method of scavenging free radicals, the method comprising:
- administering one or more free radical scavenging compounds to a dermal substrate, andreducing the levels of free radicals without significantly increasing pro-oxidant activity while the one or more free radical scavenging compounds is on the dermal substrate and is exposed to irradiation,wherein the one or more free radical scavenging compounds are selected from the group consisting of C84 fullerene and C84(Y)m, where C84 is a fullerene, Y is a moiety attached, directly or indirectly, to the C84 fullerene, where m is in the range of 1 to 30, and Y is selected from the group consisting of lipophilic moieties, hydrophilic moieties, amphiphilic moieties, free radical scavenging moieties, or bio-site specific moieties.
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Abstract
Chemically functionalized fullerenes are useful in various applications as radical scavengers. These chemically functionalized fullerenes offer the advantages of preservation of the high innate radical scavenging efficiency of the fullerene cage and ease of synthesis of fullerene derivatives of desirably altered chemical and physical properties and single isomers. Further, they are based on a common intermediate chemistry and intermediates can be easily functionalized and tailored to various requirements.
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Citations
26 Claims
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1. A method of scavenging free radicals, the method comprising:
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administering one or more free radical scavenging compounds to a dermal substrate, and reducing the levels of free radicals without significantly increasing pro-oxidant activity while the one or more free radical scavenging compounds is on the dermal substrate and is exposed to irradiation, wherein the one or more free radical scavenging compounds are selected from the group consisting of C84 fullerene and C84(Y)m, where C84 is a fullerene, Y is a moiety attached, directly or indirectly, to the C84 fullerene, where m is in the range of 1 to 30, and Y is selected from the group consisting of lipophilic moieties, hydrophilic moieties, amphiphilic moieties, free radical scavenging moieties, or bio-site specific moieties. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 25, 26)
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13. A method of scavenging free radicals, comprising:
administering to a dermal substrate a compound having the formula, - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
Specification