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Liposome compositions

  • US 7,829,113 B2
  • Filed: 03/08/2006
  • Issued: 11/09/2010
  • Est. Priority Date: 03/10/2005
  • Status: Expired due to Fees
First Claim
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1. A targeted liposome comprising one or more phosphatidylcholines, an N-(ω

  • )-dicarboxylic acid-derivatized phosphatidyl ethanolamine, a targeting factor-modified N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine, an encapsulated drug, and at least one additional lipid, which is cholesterol,wherein the mol % of the phosphatidylcholines is 40-60 mol %, the mol % of the cholesterol is 35-55 mol %, and the mol % of the total of the N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine plus targeting factor-modified N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine is 2-8 mol %, where the total mol % of the phosphatidylcholines, the cholesterol, and the derivatized phosphatidylethanolamines is 100%wherein the targeting factor-modified N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine comprises transferrin linked to a second N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine; and

    whereinthe N-(ω

    )-dicarboxylic acid-derivatized phosphatidyl ethanolamine is represented by Formula 1,

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